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1,049,261 grants matching “t cell”
Broad neutralization of pandemic threat coronaviruses
$6,423,268Paul D Bieniasz · Rockefeller University · P01 · FY2022 · AI
Flexible Hybrid Cloud Infrastructure for Seamless Integration and Use of Human Biomolecular Data and Reference Maps [1 of 5]
$6,423,244Philip D. Blood · Carnegie-Mellon University · OT2 · FY2025 · OD
Postnatal and Prenatal Therapeutic Base Editing for Metabolic Diseases
$6,415,703William H. Peranteau · Children'S Hosp Of Philadelphia · U19 · FY2023 · NS
Neuropathogenesis of Retroviral Infections
$6,412,094Avindra Nath · National Institute Of Neurological Disorders And Stroke · ZIA · FY2024 · NS
Center for Eukaryotic Structural Genomics
$6,408,784University Of Wisconsin Madison · P50 · FY2004 · GM
Infectious Disease Genomics: Pathogen Evolution, Emergence, and Host Interaction
$6,408,353Bruce W. Birren · Broad Institute, Inc. · U19 · FY2016 · AI
Project-001
$6,407,523Z Josh Huang · Cold Spring Harbor Laboratory · U19 · FY2020 · MH
THE CURRENT EXTENSION CONTINUES THE OFFER OF A FRAMEWORK TO COST-EFFECTIVELY INTEGRATE RESEARCH USING A SUITE OF MODEL ORGANISMS TO TARGET COMPLEMENTARY QUESTIONS IN HUMAN SPACEFLIGHT BY PROVIDING TO NASA POST-BACHELOR APPRENTICE SCIENTISTS THE NEXT GENERATION OF SPACE BIOLOGY LEADERS TRAINED AS ONLY BLUE MARBLE SPACE CAN IN LABORATORY AND SCIENTIFIC EXCELLENCE IN EFFECTIVE SCIENCE COMMUNICATION AND IN THE BROADER ETHICS RELATED TO THEIR WORK. THE OVERALL OBJECTIVES OF THIS EXTENSION ARE TO CONTINUE OUR SUCCESSFUL WORK IN IDENTIFYING AND IN THE PROCESS LOWERING THE COST IN IDENTIFYING QUANTITATIVELY THE EFFECT OF SPACEFLIGHT ENVIRONMENT ON MODEL ORGANISMS AND HOW THEY TRANSLATE TO THE HUMAN. THIS IS ACHIEVED BY PROVIDING A COST-EFFECTIVE TALENT POOL AND LOW OVERHEAD (BLUE MARBLE SPACE (BMS) HAS A 10% FIXED OVERHEAD RATE) COMMUNICATE AND INTEGRATE RESEARCH FINDINGS WITH THE AMES SPACE BIOLOGY COMMUNITY BY FACILITATING INTERLABORATORY COMMUNICATION SPEAR-HEADED BY BMS POST-BACHELOR APPRENTICE SCIENTISTS (THEREAFTER: POST-BACS) AND CONTINUING THE TRAINING OF THESE POST-BACS IN EFFECTIVE SCIENTIFIC COMMUNICATION AND ETHICS SKILLS. MORE SPECIFICALLY THIS EXTENSION WILL CONTINUE THE DEVELOPMENT OF A COST-EFFECTIVE INTEGRATED SCIENTIFIC FRAMEWORK FURTHERING NASA S RESEARCH AND EDUCATIONAL NEEDS. IN PARTICULAR: OBJECTIVE 1: INVESTIGATE THE LOSS OF SKELETAL FUNCTION AT THE MOLECULAR PHYSIOLOGICAL AND CELLULAR LEVEL UNDER SPACEFLIGHT CONDITIONS AND DEVELOP COUNTER MEASURES. OBJECTIVE 2: INVESTIGATE CELL REGENERATION MECHANISMS UNDER SPACEFLIGHT CONDITIONS. OBJECTIVE 3: INVESTIGATE IMMUNE SYSTEM ADAPTATION TO SPACEFLIGHT. OBJECTIVE 4: INVESTIGATE CARDIOVASCULAR AND VASCULAR ADAPTATION TO SPACEFLIGHT. OBJECTIVE 5: INVESTIGATE EUKARYOTIC CELL ADAPTATION TO RADIATION EXPOSURE UNDER SPACEFLIGHT CONDITIONS. OBJECTIVE 6: INVESTIGATE ORGAN AND ORGANISM DEVELOPMENT UNDER SPACEFLIGHT CONDITIONS. OBJECTIVE 7: INVESTIGATE ORGAN AND ORGANISM DEVELOPMENT UNDER SPACEFLIGHT CONDITIONS. EXAMINE MICROBIAL DISPERSAL USING NASA BALLOONS AIRCRAFT AND THE INTERNATIONAL SPACE STATION.
$6,405,047Blue Marble Space · · FY2020 · National Aeronautics and Space Administration
TODAY2 Phase 2 (T2P2): Long-Term Post-Intervention Follow-Up
$6,400,250Barbara Halina Braffett · George Washington University · U01 · FY2019 · DK
1. ACHIEVE 27%-EFFICIENT > 500 CM2 APERTURE AREA TANDEM MINIMODULES AFTER 6 MONTHS OF OUTDOOR TESTING IN 3 CLIMATE ZONES MADE BY HIGH-THROUGHPUT-COMPATIBLE (AT LEAST 1 M6 WAFER PER MINUTE) PEROVSKITE VAPOR DEPOSITION. 2. ACHIEVE AT MOST 10% RELATIVE PCE LOSS ON ACCELERATED TESTS THAT UTILIZE CONDITIONS SPECIFIED IN INTERNATIONAL ELECTROTECHNICAL COMMISSION (IEC) 61215 MQT10, 11, 13, AND 21 TESTS ON DAMP HEAT, THERMAL CYCLING, ULTRAVIOLET (UV) EXPOSURE, AND POTENTIAL INDUCED DEGRADATION (PID) FOR AT LEAST 15 MINIMODULES. 3. DEVELOP SCALABLE AND HIGH-THROUGHPUT-COMPATIBLE PASSIVATION THAT CAN ACHIEVE >29% TANDEM SOLAR CELLS ON >160CM2 APERTURE AREAS 4. DEVELOP A FINITE ELEMENT MODEL FOR THE MECHANICAL PROPERTIES OF COMPLETE MINIMODULES INCLUDING CELL STACK, INTERCONNECTS, AND ENCAPSULATION THAT CAN IDENTIFY STRESS CONCENTRATIONS AND PREDICT FAILURE POINTS. 5. SEND MODULES FOR OUTDOOR TESTING AT PACT THAT HAVE < 3% RELATIVE LOSS OVER 6 MONTHS.
$6,400,000Swift Solar Inc · · FY2025 · Department of Energy
Preventive Vaccines for HIV
$6,398,923Genoveffa Franchini · Division Of Basic Sciences - Nci · ZIA · FY2018 · CA
CCR Dedicated Cores at the ATRF
$6,398,664Janelle Cortner · Division Of Basic Sciences - Nci · ZIC · FY2017 · CA
CCR Dedicated Cores
$6,394,858Robin Winkler Pickett · Division Of Basic Sciences - Nci · ZIC · FY2021 · CA
Autoimmunity Center of Excellence Clinical Research Program
$6,394,853David Wofsy · University Of California, San Francisco · UM1 · FY2018 · AI
Toxicologic Pathology Evaluations for the Division of the National Toxicology Program
$6,392,686Mark Cesta · National Institute Of Environmental Health Sciences · ZIC · FY2021 · ES
Mechanisms of Beta Cell Responses in Autoimmune Disease
$6,390,755Eugene W. St Clair · Duke University · U19 · FY2011 · AI
Capital Equipment General
$6,390,275Luigi Ferrucci · National Institute On Aging · ZIC · FY2023 · AG
A comprehensive whole-brain atlas of transcriptomic cell types in the mouse
$6,386,797Hongkui Zeng · Allen Institute · U19 · FY2019 · MH
LIPID MAPS
$6,386,381University Of California San Diego · U54 · FY2003 · GM
MULTI-CENTER PHASE 2 TRIAL TO TEST ABILITY FOR STEM CELL THERAPY TO INDUCE PALMO-PLANTAR SKIN AT THE STUMP SITE OF AMPUTEES.
$6,385,838The Johns Hopkins University · · FY2018 · Defense Health Agency
CCR Dedicated Cores at the ATRF
$6,382,641Janelle Cortner · Division Of Basic Sciences - Nci · ZIC · FY2018 · CA
Martin Delaney Collaboratory to Eradicate HIV-1 Infection
$6,380,150David M. Margolis · Univ Of North Carolina Chapel Hill · U19 · FY2011 · AI
Autophagy Modulators as Novel Broad-Spectrum Anti-Infective Agents
$6,377,610Herbert W Virgin · Washington University · U19 · FY2014 · AI
A Data Resource for Blood and Marrow Transplants and Adoptive Cellular Therapy Research
$6,375,686Bronwen Shaw · Medical College Of Wisconsin · U24 · FY2024 · CA
SAN DIEGO CHEMICAL LIBRARY SCREENING CENTER(RMI)
$6,375,675John C Reed · Sanford Burnham Prebys Medical Discovery Institute · U54 · FY2007 · HG