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38,696 grants matching “als”
Genomic profiling of influenza infections to identify biomarkers of disease severity
$1,439,918Elodie Ghedin · National Institute Of Allergy And Infectious Diseases · ZIA · FY2023 · AI
Genetic Aspects Of Viral Oncogenesis In Inbred Strains and Wild Mouse Species
$1,439,161Christine Kozak · National Institute Of Allergy And Infectious Diseases · ZIA · FY2022 · AI
MENTAL DISORDERS AS RISK FACTORS FOR SUBSTANCE DISORDERS
$1,439,042Harvard University (Medical School) · R01 · FY2000 · DA
Bioinformatics
$1,438,740Ming Zhan · National Institute On Aging · ZIC · FY2009 · AG
Therapeutics targeting TDP-43 to treat Alzheimer's disease and related disorders
$1,438,738Allen Bernard Reitz · Fox Chase Chemical Diversity Center, Inc · U01 · FY2025 · AG
RNA-DIRECTED THERAPY FOR C9ORF72-LINKED ALS
$1,437,292University Of California, San Diego · · FY2019 · Department of the Army
Motor Activity Research Consortium for Health (mMarch)
$1,436,888Kathleen R Merikangas · National Institute Of Mental Health · ZIA · FY2023 · MH
IGF-I/ALS Trial
$1,436,847Mayo Clinic · R01 · FY2005 · NS
Genome-wide analysis of chromatin modifications
$1,435,783Keji Zhao · National Heart, Lung, And Blood Institute · ZIA · FY2022 · HL
Technical Development of Diagnostic Cardiovascular MRI
$1,435,728Andrew Arai · National Heart, Lung, And Blood Institute · ZIA · FY2018 · HL
The Role of Protein Methylation in Squamous Cell Carcinoma of the Head and Neck
$1,435,614Vassiliki Saloura · Division Of Basic Sciences - Nci · ZIA · FY2025 · CA
Regulation of Ras-Dependent Signal Transduction Pathways
$1,435,512Deborah Morrison · Division Of Basic Sciences - Nci · ZIA · FY2025 · CA
Pathophysiology of genetically defined dementia and neurodegeneration: Defining therapeutic targets and pathways
$1,435,400Matthew D Disney · Scripps Florida · P01 · FY2018 · NS
Pathophysiology of genetically defined dementia and neurodegeneration: Defining therapeutic targets and pathways
$1,435,400Matthew D Disney · Scripps Florida · P01 · FY2019 · NS
Comparative Genomics Analysis Unit Research
$1,435,098James C Mullikin · National Human Genome Research Institute · ZIA · FY2021 · HG
Regulation of Oxytocin and Vasopressin Gene Expression in the hypothalamus.
$1,434,263Harold Gainer · National Institute Of Neurological Disorders And Stroke · ZIA · FY2012 · NS
Restoring Communication with an Intracortical Neural Interface System
$1,433,748Leigh R Hochberg · Massachusetts General Hospital · R01 · FY2009 · DC
Oncogenic Kinases in Cancer
$1,433,387John Brognard · Division Of Basic Sciences - Nci · ZIA · FY2021 · CA
SUMMARY THE UNIVERSITY OF CALIFORNIA IRVINE (UCI) HAS MONITORED GLOBAL TRACE GAS CONCENTRATIONS SINCE 1978 WITH FUNDING SUPPORT FROM NASA SINCE 1984. THE PROGRAM TARGETS COMPOUNDS THAT IMPACT THE ATMOSPHERE S CHEMISTRY AND RADIATIVE FORCING INCLUDING GREENHOUSE GASES (E.G. CH4) STRATOSPHERIC OZONE DEPLETING AGENTS (E.G. CFCS CH3CCL3) LIGHT HYDROCARBONS (E.G. ETHANE PROPANE) INDUSTRIAL SOLVENTS (E.G. C2CL4 CHCL3) CARBON MONOXIDE (CO) AND LIGHT ORGANIC NITRATES (E.G. MEONO2 ETONO2). THE MULTI-DECADE MEASUREMENTS OF LIGHT HYDROCARBONS ARE UNIQUE TO THE UCI GLOBAL MONITORING NETWORK AS ARE LONG-TERM MEASUREMENTS OF ALKYL NITRATES AND C2CL4. THE UCI DATA ARE AVAILABLE TO THE ATMOSPHERIC SCIENCE COMMUNITY VIA THE CARBON DIOXIDE INFORMATION ANALYSIS CENTER (CDIAC) ARCHIVE AND THE GLOBAL ATMOSPHERIC WATCH (GAW) WORLD DATA CENTER FOR GREENHOUSE GASES (WDCGG). THE UCI DATA ARE REGULARLY USED IN INTERNATIONAL REPORTS MOST RECENTLY THE 2013 ASSESSMENT REPORT OF THE INTERGOVERNMENTAL PANEL ON CLIMATE CHANGE (HARTMANN ET AL. 2013) AND THE 2014 SCIENTIFIC ASSESSMENT OF OZONE DEPLETION (CARPENTER AND REIMANN 2014). UCI S LONG-TERM GLOBAL ETHANE DATA HAVE BEEN USED BY SEVERAL GROUPS TO BETTER UNDERSTAND WHY THE GLOBAL GROWTH RATE OF ATMOSPHERIC CH4 HAS DECLINED IN THE LONG TERM (AYDIN ET AL. 2011; KAI ET AL. 2011; SIMPSON ET AL. 2012; KIRSCHKE ET AL. 2013). THE ETHANE DATA HAVE ALSO BEEN USED BY MODELING GROUPS FOR VARIOUS PURPOSES INCLUDING NOAA (TO INVESTIGATE LONG-TERM GLOBAL CH4 AND ETHANE TRENDS; SIMPSON ET AL. 2012) CARNEGIE MELLON (TO QUANTIFY FUGITIVE EMISSION RATES OF NATURAL GAS; SCHWIETZKE ET AL. 2014) AND MAX PLANCK (TO CONSTRAIN CH4 EMISSIONS FROM TROPICAL WETLANDS; NU EZ ET AL. 2015). UCI S GLOBAL DATA SET IS CURRENTLY BEING USED BY THE NCAR MODELING COMMUNITY AS PART OF THE IGAC/SPARC CHEMISTRY CLIMATE MODEL INITIATIVE (CCMI) BY THE MODELING COMMUNITY AT FLORIDA STATE UNIVERSITY (FSU) TO INVESTIGATE GEOGENIC ETHANE EMISSIONS AND BY NOAA/INSTAAR TO CONSTRAIN RECENT ETHANE AND PROPANE TRENDS. OUR BROAD GOALS FOR THE UPCOMING 2016-2021 FUNDING PERIOD ARE TO CONTINUE TO MONITOR KEY CONSTITUENTS OF THE EARTH S ATMOSPHERE COLLABORATE WITH THE BROADER RESEARCH COMMUNITY AND ARCHIVE PUBLISH AND DISSEMINATE OUR MAJOR FINDINGS. OUR SPECIFIC OBJECTIVES ARE AS FOLLOWS: (1) CONTINUED SEASONAL AIR SAMPLING IN REMOTE REGIONS OF THE PACIFIC BASIN. AS WE HAVE DONE FOR MORE THAN 35 YEARS WE WILL CONTINUE TO COLLECT 60-80 GROUND-LEVEL WHOLE AIR SAMPLES AT 40-50 REMOTE SITES IN A GLOBAL LATITUDINAL TRANSECT THE PACIFIC BASIN (71 N TO 47 S). EACH AIR SAMPLE WILL BE RETURNED TO UCI AND ANALYZED FOR UP TO 55 COMPOUNDS WITH 16 VOLATILE ORGANIC COMPOUNDS (VOCS) SUBMITTED TO THE CDIAC AND WDCGG DATA ARCHIVES. (2) CONTINUED PUBLICATION. THE JOURNAL ELEMENTA HAS LAUNCHED A GAW SPECIAL FEATURE ENTITLED REACTIVE GASES IN THE GLOBAL ATMOSPHERE. FOLLOWING OUR RECENT DATA SUBMISSION TO THE GAW WDCGG ARCHIVE WE PROPOSE TO SUBMIT AN OVERVIEW PAPER SUMMARIZING THE UCI NETWORK AND PRESENTING OUR GLOBAL DATA FOR THE ARCHIVED TRACE GASES. OTHER FINDINGS WILL BE PUBLISHED THROUGHOUT THE 2016-2021 FUNDING PERIOD IN COLLABORATION WITH OUR COLLEAGUES. (3) ON-GOING COLLABORATIONS. OUR LONG-TERM GLOBAL ETHANE DATA ARE PARTICULARLY VALUABLE TO MODELERS AND TO OTHER EXPERIMENTALISTS ESPECIALLY TOWARDS EFFORTS TO CONSTRAIN SOURCES AND TRENDS OF ATMOSPHERIC CH4. WE WILL CONTINUE THESE COLLABORATIONS DURING 2016-2021. (4) QUANTIFICATION OF H2 USING A NEW REDUCED GAS DETECTOR. MOLECULAR HYDROGEN (H2) CONTRIBUTES TO STRATOSPHERIC WATER VAPOR AND THE HOX CYCLE. WE RECENTLY ACQUIRED A DETECTOR FOR H2 ANALYSIS AND WE HAVE MEASURED A WELL-DEFINED INTERHEMISPHERIC GRADIENT FOR H2. WE WILL INCORPORATE GLOBAL H2 MEASUREMENTS INTO OUR ROUTINE GLOBAL MONITORING.
$1,433,026University Of California Irvine · · FY2017 · National Aeronautics and Space Administration
Molecular Mechanisms Regulating Mouse Mammary Gland and Human Breast Tumor Cells
$1,432,735Gisela Sterneck · Division Of Basic Sciences - Nci · ZIA · FY2022 · CA
improving outcomes after stem cell transplantation
$1,432,613Austin J Barrett · National Heart, Lung, And Blood Institute · ZIA · FY2016 · HL
Clinical Psychoneuroendocrinology and Neuropsychopharmacology (CPN)
$1,432,347Lorenzo Leggio · National Institute On Alcohol Abuse And Alcoholism · ZIA · FY2014 · AA
Molecular and Cellular Mechanisms of Experience-Dependent Cortical Processing
$1,430,692Kuan Wang · National Institute Of Mental Health · ZIA · FY2010 · MH
Genetic Basis Of Cortical Malfunction In Schizophrenia
$1,429,547Karen Faith Berman · National Institute Of Mental Health · ZIA · FY2013 · MH
Neuronal Ion Channel Modulation By Second Messengers
$1,428,943Stephen R Ikeda · National Institute On Alcohol Abuse And Alcoholism · ZIA · FY2012 · AA