Sort
17,054 grants matching “genome editing”
Gene Transfer Core, NIDCR-DIR
$888,387Ashok Kulkarni · National Institute Of Dental & Craniofacial Research · ZIC · FY2021 · DE
WITH REGARD TO GENETIC IMPROVEMENT FOR DEVELOPING DISEASE RESISTANCE, TREE SPECIES IN COMPARISON TO ANNUALS REPRESENT A SERIOUS CHALLENGE. CITRUS BACTERIAL CANKER CAUSED BY XANTHOMONAS CITRI SSP. CITRI (XCC) IS ONE OF THE MOST DEVASTATING DISEASES OF CITRUS IN THE WORLD AND DEVELOPING RESISTANCE TO THIS DISEASE IS A DAUNTING TASK. GENERATING CANKER RESISTANT CITRUS VARIETIES WOULD BE THE MOST SUSTAINABLE AND ECONOMICAL SOLUTION TO CONTROL CANKER. HOWEVER, CITRUS BREEDING HAS OFTEN BEEN HINDERED BY POLYEMBRYONY, POLLEN-OVULE STERILITY, SEXUAL AND GRAFT INCOMPATIBILITIES, AND EXTENDED JUVENILITY. HERE, WE PROPOSE TO EXPLOIT CRISPR TECHNOLOGY AND A SPECIFIC DISEASE-SUSCEPTIBILITY GENE IN CITRUS TO GENERATE CANKER RESISTANT PLANTS. CSLOB1 (CITRUS SINENSIS LATERAL ORGAN BOUNDARIES), WHICH IS A CRITICAL CITRUS SUSCEPTIBILITY GENE THAT THE CITRUS CANKER PATHOGEN XCC TARGETS, IS A MEMBER OF THE LATERAL ORGAN BOUNDARIES DOMAIN (LBD) GENE FAMILY OF TRANSCRIPTION FACTORS. ALL STRAINS OF XCC ENCODE A TRANSCRIPTION ACTIVATOR-LIKE (TAL) EFFECTOR THAT RECOGNIZES AN EFFECTOR BINDING ELEMENT (EBE) IN THE PROMOTER OF CSLOB1 AND INDUCES GENE EXPRESSION. CITRUS CANKER REPRESENTS A MODEL DISEASE FOR THE ASSESSMENT OF GENOME EDITING FOR THE ENHANCEMENT OF TREE GERMPLASM. THE PROJECT WILL GENERATE EDITED PLANTS AND ASSESS THE CONSEQUENCES OF EDITING. FURTHERMORE, EXPERIMENTS ARE PROPOSED THAT WILL PROVIDE INSIGHT INTO THE ABILITY OF THE PATHOGEN TO OVERCOME EDITING BY ADAPTATION. ACCOMPLISHMENTS FROM THIS PROJECT WILL PAVE THE WAY FOR GENERATING NON-TRANSGENIC PLANTS IN OTHER TREE CROPS FOR IMPROVING TRAITS SUCH AS DISEASE RESISTANCE, FLOWERING TIME, AND YIELD.
$887,788University Of Florida · · FY2017 · National Institute of Food and Agriculture
Systems Genetics Analysis of Alzheimer's Disease-Related Sleep Loss and the Transition to Dementia
$887,525Catherine Cook Kaczorowski · Jackson Laboratory · R01 · FY2022 · AG
Identifying functional variants in COPD GWAS loci
$886,769Edwin K Silverman · Brigham And Women'S Hospital · R01 · FY2019 · HL
The Genetics and Neural Mechanisms of Preference Learning
$886,277Erica L Westerman · University Of Arkansas · · FY2020 · BIO
(PQ8) Genetically faithful murine models for studying disease progression in chronic lymphocytic leukemia
$885,964Catherine Ju-Ying Wu · Dana-Farber Cancer Inst · R01 · FY2019 · CA
Elicitation of HIV Broadly Neutralizing Antibodies from Engineered B cells
$885,861James Even Voss · Scripps Research Institute, The · R01 · FY2021 · AI
Mechanisms of regulation by RNA in acute myeloid leukemia
$885,280Daniel G Tenen · Beth Israel Deaconess Medical Center · R35 · FY2017 · CA
Regulation of Proinflammatory Cytokine Responses by a Caspase-8-N4BP1 Axis
$885,000Alexander Gitlin · Sloan-Kettering Inst Can Research · DP5 · FY2025 · OD
Function interactions between mitogen-activated protein kinases (MAPKs) and SARS-CoV-2
$883,797Jeffrey R Johnson · Icahn School Of Medicine At Mount Sinai · R01 · FY2023 · AI
Functional consequences of intergenic autoimmune disease risk variants
$883,641Timothy B Niewold · Hospital For Special Surgery · R01 · FY2023 · AI
RNAi Screening in Hematopoietic Cells
$883,556Iain Fraser · National Institute Of Allergy And Infectious Diseases · ZIA · FY2020 · AI
Human iPSC Model for Elucidating Crosstalk Signaling and Secretomes
$882,881Joseph C Wu · Stanford University · R01 · FY2020 · HL
Analysis of Dominant Megacolon: Another Hirschsprung Disease Model
$882,181William J Pavan · National Human Genome Research Institute · ZIA · FY2017 · HG
Development of 211Astatine-Conjugated Anti-CD45 Antibody-Based Conditioning for Hematopoietic Stem Cell Gene Therapy and Editing
$881,880Roland Bruno Walter · Fred Hutchinson Cancer Research Center · R01 · FY2020 · HL
In vivo hematopoietic stem cell engineering for HIV cure
$880,758Hans-Peter Kiem · University Of Southern California · P01 · FY2025 · HL
CAREER: Specify germ cell lineages from pluripotent state
$880,000Yuan Wang · Michigan State University · · FY2021 · BIO
Gene Function, Expression and Regulation in Zebrafish
$879,907Benjamin Feldman · Eunice Kennedy Shriver National Institute Of Child Health & Human Development · ZIC · FY2019 · HD
Short-term and long-term effects of methamphetamine exposure on residual viral transcription during treated HIV disease
$879,803Sulggi Angela Lee · University Of California, San Francisco · R33 · FY2024 · DA
Resilience pathways modeling human longevity-promoting ApoE variants in induced pluripotent stem cells
$879,592Lisa M. Ellerby · Buck Institute For Research On Aging · R01 · FY2020 · AG
Resilience pathways modeling human longevity-promoting ApoE variants in induced pluripotent stem cells
$879,592Lisa M. Ellerby · Buck Institute For Research On Aging · R01 · FY2021 · AG
Resilience pathways modeling human longevity-promoting ApoE variants in induced pluripotent stem cells
$879,592Lisa M. Ellerby · Buck Institute For Research On Aging · R01 · FY2018 · AG
Resilience pathways modeling human longevity-promoting ApoE variants in induced pluripotent stem cells
$879,592Lisa M. Ellerby · Buck Institute For Research On Aging · R01 · FY2019 · AG
Resilience pathways modeling human longevity-promoting ApoE variants in induced pluripotent stem cells
$879,592Lisa M. Ellerby · Buck Institute For Research On Aging · R01 · FY2022 · AG
Identifying functional variants in COPD GWAS loci
$877,981Edwin K Silverman · Brigham And Women'S Hospital · R01 · FY2018 · HL