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38,696 grants matching “als”
Axonal transport of endolysosomal organelles and presynaptic cargos for the maintenance of axon cellular homeostasis and presynaptic function
$1,330,929Zu-Hang Sheng · National Institute Of Neurological Disorders And Stroke · ZIA · FY2023 · NS
CLINICAL RESEARCH CENTER FOR NEUROMUSCULAR DISEASE
$1,329,297Columbia University Health Sciences · P01 · FY2003 · NS
Preclinical Evaluation Of PET Radiotracers
$1,328,580Robert Innis · National Institute Of Mental Health · ZIA · FY2013 · MH
Development of MRI Techniques for Drug-Abuse Applications
$1,328,133Yihong Yang · National Institute On Drug Abuse · ZIA · FY2021 · DA
What determines the location of meiotic crossovers in the mammalian genome?
$1,327,881Rafael Camerini-Otero · National Institute Of Diabetes And Digestive And Kidney Diseases · ZIA · FY2015 · DK
The different pathways involved in meiotic recombination in mammals
$1,327,881Rafael Camerini-Otero · National Institute Of Diabetes And Digestive And Kidney Diseases · ZIA · FY2015 · DK
Development and modification of neural circuitry in the mammalian olfactory bulb
$1,327,686Leonardo Belluscio · National Institute Of Neurological Disorders And Stroke · ZIA · FY2009 · NS
Comparative Genomics Unit Research
$1,327,152James C Mullikin · National Human Genome Research Institute · ZIA · FY2013 · HG
Post-Transcriptional Regulation of Interleukin-7 Receptor Expression
$1,326,749Jung-Hyun Park · Division Of Basic Sciences - Nci · ZIA · FY2023 · CA
Neuro-exergaming for the Prevention and Remediation of Decline due to Parkinson's Disease: Clinical Trial of the Interactive Physical and Cognitive Exercise System (iPACES v3)
$1,326,588Robert Willson Gillen · Ipaces, Llc · R44 · FY2023 · NS
Synaptic Vesicle Exocytosis
$1,326,078Ling Gang Wu · National Institute Of Neurological Disorders And Stroke · ZIA · FY2010 · NS
Synaptic Vesicle Endocytosis
$1,326,078Ling Gang Wu · National Institute Of Neurological Disorders And Stroke · ZIA · FY2010 · NS
ALS Efficiently Networking Advanced Beam Line Experiments (ALS-ENABLE)
$1,326,074Paul David Adams · University Of Calif-Lawrenc Berkeley Lab · P30 · FY2017 · GM
Walking Forward - American Indian Participation in Cancer Clinical Trials
$1,325,000Daniel G Petereit · Rapid City Regional Hospital · U54 · FY2009 · CA
Disease mechanisms in myofibrillar myopathies
$1,323,586Ami Mankodi · National Institute Of Neurological Disorders And Stroke · ZIA · FY2015 · NS
Fibroproliferative mechanisms in organ fibrosis
$1,323,322Resat Cinar · National Institute On Alcohol Abuse And Alcoholism · ZIA · FY2022 · AA
Development of MRI Techniques for Drug-Abuse Applications
$1,321,564Yihong Yang · National Institute On Drug Abuse · ZIA · FY2019 · DA
Cancer Biology and Genetics
$1,321,500Harold Varmus · National Human Genome Research Institute · ZIA · FY2012 · HG
Human pluripotent stem cells
$1,320,955Pamela Robey · National Institute Of Neurological Disorders And Stroke · ZIC · FY2017 · NS
ISOTOPIC INVESTIGATIONS RELEVANT TO ORIGINS OF SOLAR SYSTEMS:WE PROPOSE TO APPLY HIGH-PRECISION 26AL-26MG AND 53MN-53CR CHRONOMETERS TO KEY "MILESTONES" OF THE EARLY SOLAR NEBULA - IN ORDER TO SHED LIGHT ON THE TIMESCALES OF PLANETARY BUILDING PROCESSES. WE WILL USE MULTICOLLECTOR INDUCTIVELY COUPLED PLASMA MASS SPECTROMETRY TO PERFORM HIGH PRECISION ISOTOPIC ANALYSES FOR THE PROPOSED WORK. THE NECESSARY EXPERIMENTAL TECHNIQUES WERE DEVELOPED IN THE PI'S LAB FROM THE PRIOR FUNDING CYCLE OF THE ORIGINS PROGRAM - AND HAVE BEEN SUCCESSFULLY APPLIED TO CA-AL-RICH INCLUSIONS (AL-MG) AND CHONDRULES (MN-CR) EXTRACTED FROM PRIMITIVE METEORITES. SECOND - WE PROPOSE A LABORATORY EXPERIMENT TO TEST THE "SELF-SHIELDING" MODEL ADVANCED TO EXPLAIN THE OXYGEN ISOTOPE DISTRIBUTION IN EARLY SOLAR SYSTEM MATERIALS. WE WILL USE THE NEWLY ESTABLISHED ULTRAHIGH-RESOLUTION VACUUM ULTRAVIOLET LASER PHOTODISSOCIATION AND PHOTOIONIZATION FACILITY OF C.Y. NG (CO-I) TO PERFORM CO PHOTODISSOCIATION EXPERIMENTS. WE PROPOSE A DETAILED EXPERIMENTAL SET-UP AND PROCEDURES THAT WOULD ENSURE THE EXPERIMENTAL CONDITIONS ARE REFLECTIVE OF THE SOLAR NEBULAR PHOTOCHEMISTRY OF CO. WE DESCRIBE OUR UNIQUE CAPABILITY AND PREPAREDNESS TO PERFORM THIS TIMELY EXPERIMENT. THE SUCCESS OF THIS EXPERIMENT - TOGETHER WITH OXYGEN ISOTOPE DATA FROM THE GENESIS MISSION - WILL PROVIDE A CRUCIAL PIECE OF INFORMATION IN UNDERSTANDING THE PUZZLE OF THE OBSERVED OXYGEN ISOTOPE ANOMALIES IN THE SOLAR SYSTEM - KNOWN FOR OVER THREE DECADES BUT DEFYING A CONSENSUS EXPLANATION TO THIS DAY. THIS EXPERIMENTALLY-FOCUSED RESEARCH PROPOSAL IS HIGHLY RELEVANT TO THE SCOPE OF THE ORIGINS OF SOLAR SYSTEMS PROGRAM: THROUGH THE LABORATORY ANALYSIS OF PRIMITIVE MATERIALS TO UNDERSTAND THE DIVERSITY OF CHEMICAL AND PHYSICAL CONDITIONS IN THE SOLAR NEBULA LEADING TO THE FORMATION OF PLANETARY SYSTEMS. THE PROPOSED INVESTIGATION SUPPORTS ONE OF THE FOUR GOALS OF THE ORIGINS OF SOLAR SYSTEMS PROGRAM: STUDIES OF CHEMICAL AND ATOMIC PROCESSES RELATED TO THE FORMATION OF PLANETARY SYSTEMS. THE PROPOSAL REPRESENTS AN OPPORTUNITY FOR COLLABORATIVE RESEARCH WITH THE EXISTING POTENTIAL AT UNIVERSITY OF CALIFORNIA AT DAVIS FOR COMPLEMENTARY INTERDISCIPLINARY EFFORTS TO SOLVE KEY SCIENTIFIC QUESTIONS - AS ENCOURAGED EXPLICITLY BY THE ORIGINS OF SOLAR SYSTEMS PROGRAM. THE PROPOSED RESEARCH ACTIVITIES SUPPORT NASA STRATEGIC GOALS (SUB-GOAL 3C) TO ADVANCE SCIENTIFIC KNOWLEDGE OF THE ORIGIN AND HISTORY OF THE SOLAR SYSTEM. THE OUTCOME OF THE PROPOSED RESEARCH WILL LEAD TO PROGRESS IN LEARNING HOW THE SUN S FAMILY OF PLANETS AND MINOR BODIES ORIGINATED AND EVOLVED (NASA RESEARCH OBJECTIVE 3C.1) - AND IN UNDERSTANDING HOW INDIVIDUAL STARS FORM AND HOW THOSE PROCESSES ULTIMATELY AFFECT THE FORMATION OF PLANETARY SYSTEMS (NASA RESEARCH OBJECTIVE 3D.3). OUR EFFORTS WILL HELP TO ATTRACT AND RETAIN STUDENTS IN SCIENCE / TECHNOLOGY / ENGINEERING / AND MATHEMATICS DISCIPLINES (STEM); THUS STRENGTHENING NASA AND THE NATION S FUTURE WORKFORCE - AND ENGAGE MORE AMERICANS IN NASA'S MISSION.
$1,320,883University Of California, Davis · · FY2009 · National Aeronautics and Space Administration
Administration Core
$1,320,867Paul David Adams · University Of Calif-Lawrenc Berkeley Lab · P30 · FY2023 · GM
fMRI Study of Motivation, Decision-Making, Reward, Risk, Aversion, Craving, impulsivity, and Stress in Alcohol Use Disorders
$1,320,330Abdolreza Momenan · National Institute On Alcohol Abuse And Alcoholism · ZIA · FY2018 · AA
Gulf Longitudinal Follow-up (GuLF) Study
$1,320,053Dale P Sandler · National Institute Of Environmental Health Sciences · ZIA · FY2019 · ES
Resource for the Development of Biomedical Accelerator Mass Spectrometry (AMS)
$1,319,759Kenneth W Turteltaub · University Of Calif-Lawrnc Lvrmr Nat Lab · P41 · FY2015 · GM
Genomic Architecture of Progression and Treatment Response in AMD
$1,318,758Margaret A Pericak-Vance · University Of Miami School Of Medicine · R01 · FY2013 · EY