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16,300 grants matching “fatty liver disease”
Mechanisms connecting dysregulated BCAA, glucose & lipid metabolism in the pathogenesis of metabolic disease
$651,201Christopher B Newgard · Duke University · R01 · FY2022 · DK
HIV-induced monocyte and macrophage perturbations driving liver fibrogenesis
$650,980Nadia Alatrakchi · Massachusetts General Hospital · R56 · FY2022 · DK
Validation of targets for therapeutic intervention in NASH
$650,969Brian Robert Wamhoff · Hemoshear Therapeutics, Llc · R44 · FY2018 · DK
Defining mechanisms of extracellular succinate regulation over metabolic tissue function
$650,788Edward Thomas Chouchani · Dana-Farber Cancer Inst · R01 · FY2024 · DK
Defining mechanisms of extracellular succinate regulation over metabolic tissue function
$650,788Edward Thomas Chouchani · Dana-Farber Cancer Inst · R01 · FY2025 · DK
The NRF2-FBP1 crossregulatory loop and the control of healthy and diseased liver metabolism
$650,734Michael Karin · University Of California, San Diego · R01 · FY2024 · DK
Metabolic regulation and inhibition of ATP-citrate lyase
$650,357Ronen Marmorstein · University Of Pennsylvania · R01 · FY2022 · CA
Bile acids and insulin sensitivity
$650,344Rebecca Anne Haeusler · Columbia University Health Sciences · R01 · FY2021 · DK
Deciphering Mechanisms for Triglyceride and Cholesterol Transport
$650,190Stephen G Young · University Of California Los Angeles · P01 · FY2023 · HL
Deciphering Mechanisms for Triglyceride and Cholesterol Transport
$650,190Stephen G Young · University Of California Los Angeles · P01 · FY2020 · HL
Deciphering Mechanisms for Triglyceride and Cholesterol Transport
$650,190Stephen G Young · University Of California Los Angeles · P01 · FY2021 · HL
Deciphering Mechanisms for Triglyceride and Cholesterol Transport
$650,190Stephen G Young · University Of California Los Angeles · P01 · FY2022 · HL
Managing Atherosclerosis by Modulating HDL Function
$649,985M. Reza Ghadiri · Scripps Research Institute, The · R01 · FY2014 · HL
Metabolic impact of FGF-21 in adipose tissue and liver of PLWH
$649,982Jordan E Lake · University Of Texas Hlth Sci Ctr Houston · R01 · FY2021 · DK
Pathophysiologic mechanisms leading to intrahepatic fat accumulation in obese youth
$649,955Nicola Santoro · University Of Kansas Medical Center · R01 · FY2023 · MD
Mechanisms of Alcoholic Liver Disease
$649,597Bin Gao · National Institute On Alcohol Abuse And Alcoholism · ZIA · FY2009 · AA
** AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** COCOA IS A POPULAR FOOD INGREDIENT. RESEARCH FROM OUR LABORATORY AND OTHERS HAVE SHOWN THAT DIETARY COCOA CAN MITIGATE OBESITY-RELATED INFLAMMATION AND NON-ALCOHOLIC FATTY LIVER DISEASE (NAFLD). THE EFFECTS ARE RELATED TO IMPROVED GUT HEALTH. OUR RESEARCH TEAM RECENTLY PUBLISHED TWO PAPERS SHOWING SIGNIFICANT DIFFERENCES IN THE RESPONSE OF OBESE MICE TO DIETARY COCOA BASED ON SEX. PRIOR STUDIES HAVE REPORTED THAT SEX AND SEX HORMONES CAN IMPACT DEVELOPMENT OF NAFLD AND OTHER CO-MORBIDITIES OF OBESITY IN GUTMICROBIOTA-DEPENDENT AND INDEPENDENT WAYS. BASED ON THIS, WE HYPOTHESIZE THAT DIETARY COCOA MITIGATES INFLAMMATION AND NAFLD IN OBESE MICE IN A SEX-SPECIFIC MANNER, AND THAT THE INFLUENCE OF SEX HORMONES ON THE COMPOSITION OF THE GUT MICROBIOME AND MAMMALIAN SIGNALING PATHWAYS DRIVE THESE DIFFERENCES IN BIOLOGICAL RESPONSE. WE WILLCHARACTERIZE THE SEX-SPECIFIC BENEFICIAL EFFECTS OF COCOA AGAINST OBESITY-RELATED ENTEROHEPATIC INFLAMMATION AND FATTY LIVER DISEASE. ADDITIONALLY, WE WILLCHARACTERIZE THE ROLE OF THE GUTMICROBIOME IN MEDIATING THE SEX-SPECIFIC EFFECTS OF COCOA AGAINST OBESITY-RELATED INFLAMMATION AND LIVER DISEASE.THESE STUDIES WILL PROVIDE GREATER INSIGHT INTO THE ANTI-INFLAMMATORY AND ENTEROHEPATIC PROTECTIVE ACTIVITY OF COCOA, AND THE IMPACT OF SEX AS MODERATOR. THESE DATA WILL SUPPORT THE DEVELOPMENT OF PERSONALIZED NUTRITIONAL APPROACHES AND NOVEL PRODUCTS CONTAINING COCOA TO IMPROVE HUMANHEALTH.
$649,588The Pennsylvania State University · · FY2024 · National Institute of Food and Agriculture
Integrative Polygenic Genetic Studies of Non-alcoholic Fatty Liver Disease
$649,576Elizabeth K Speliotes · University Of Michigan At Ann Arbor · R01 · FY2024 · DK
Exercise effects on adipose tissue morphology, metabolic function, and metabolic health with weight loss and weight regain in obesity
$649,395Jeffrey F Horowitz · University Of Michigan At Ann Arbor · R01 · FY2023 · DK
Triglycerides as a Predictor of Newborn Subcutaneous and Liver Fat: Contributors to Fetal Fat Accretion in Obese Pregnancies
$649,276Linda A Barbour · University Of Colorado Denver · R01 · FY2024 · HD
Roles of ANGPTL3 and ANGPTL8 in Lipid and Energy Metabolism
$649,158Helen H. Hobbs · Ut Southwestern Medical Center · P01 · FY2021 · HL
Roles of ANGPTL3 and ANGPTL8 in Lipid and Energy Metabolism
$649,158Helen H. Hobbs · Ut Southwestern Medical Center · P01 · FY2019 · HL
Roles of ANGPTL3 and ANGPTL8 in Lipid and Energy Metabolism
$649,158Helen H. Hobbs · Ut Southwestern Medical Center · P01 · FY2020 · HL
Roles of ANGPTL3 and ANGPTL8 in Lipid and Energy Metabolism
$649,157Helen H. Hobbs · Ut Southwestern Medical Center · P01 · FY2017 · HL
Metabolomic predictors of insulin resistance and diabetes
$649,027Robert E Gerszten · Beth Israel Deaconess Medical Center · R01 · FY2025 · DK