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15,273 grants matching “antimicrobial resistance”
Discovery of Gram-negative permeable chemical probes for tRNA methylation
$684,222Ya-Ming Hou · Thomas Jefferson University · R01 · FY2022 · AI
Discovery of Gram-negative permeable chemical probes for tRNA methylation
$684,222Ya-Ming Hou · Thomas Jefferson University · R01 · FY2021 · AI
Functional Genomics Core
$683,913Anthony Haag · University Of Texas Hlth Sci Ctr Houston · P01 · FY2021 · AI
Effect of Microbial Metabolites on Growth of Cryptosporidium
$683,892L David Sibley · Washington University · R01 · FY2020 · AI
Task 6: Technical Support for Tuberculosis Therapeutics
$683,747Jon Carl Mirsalis · Sri International · N01 · FY2017 · AI
Newly Identified mechanisms of Ceftaroline Resistance in MRSA Clinical Strains
$683,638Adriana E Rosato · Methodist Hospital Research Institute · R56 · FY2016 · AI
HTS for copper-activated inhibitors against MRSA
$683,442Frank Wolschendorf · University Of Alabama At Birmingham · R01 · FY2017 · AI
Polymyxin-resistant Pseudomonas in CF Lung Infection
$683,379Samuel M Moskowitz · Massachusetts General Hospital · R01 · FY2010 · AI
Lung Resident, MR1-Restricted T Cells: Association with Differential Outcomes Following Exposure to M. Tuberculosis
$683,274David M. Lewinsohn · Oregon Health & Science University · R01 · FY2021 · AI
The joint environment and periprosthetic joint infection
$683,063Noreen J Hickok · Thomas Jefferson University · R01 · FY2023 · AR
Focused Ultrasound Treatment of Skin and Soft Tissue Abscesses
$682,655Thomas Matula · University Of Washington · R01 · FY2025 · AR
Redefining Tuberculosis Meningitis with Metagenomics and Host Transciptomics
$682,642Michael R Wilson · University Of California, San Francisco · R01 · FY2021 · AI
DISRUPTION OF BACTERIAL OUTER MEMBRANES (OM) BY ANTIMICROBIAL AGENTS IS A MAJOR AREA OF PROMISE FOR BIOCONTROL AND PLANT DISEASE RESISTANCE. EXAMPLES INCLUDE BACTERIALLY PRODUCED TOXINS, TERMED TAILOCINS, WHICH SHOW EXCELLENT PROMISE FOR SPECIFIC AND ENGINEERABLE PROPHYLAXIS. ADDITIONALLY, LPS TARGETING ANTIMICROBIAL PEPTIDES (AMP) ARE THE MAJOR DIFFERENCE BETWEEN HUANGLONGBING (HLB) RESISTANT AND SUSCEPTIBLE PLANTS. INDEED, PLANTS ARE KNOWN TO PRODUCE AN ARRAY OF AMPS THAT KILL MICROBES THROUGH MEMBRANE DISRUPTION. DESPITE THIS PROMISE, WE'VE SHOWN THAT BACTERIA CAN ENTER TEMPORARY PHYSIOLOGICAL STATES THAT MAKE THEM TOLERANT TO MEMBRANE-ACTIVE TREATMENTS, A PHENOMENON TERMED PERSISTENCE. SUCH PERSISTENCE COMPLICATES THE EFFECTIVENESS OF THESE TREATMENTS. MOREOVER, MODELING HAS PREDICTED FOR MANY ANTIMICROBIALS, INCLUDING THOSE THAT ARE OM-TARGETING, THAT PERSISTENCE CAN SPEED THE EVOLUTION OF RESISTANCE, FURTHER IMPEDING OUR ABILITY TO DEPLOY THESE AGENTS FOR LONG-TERM CONTROL. THUS, UNDERSTANDING THE PREVALENCE AND MECHANISMS OF SURVIVAL TO OM-TARGETING TREATMENTS WILL BE CRITICAL FOR DETERMINING UNDER WHAT CONDITIONS THESE TREATMENTS WILL BE DURABLE AND EFFECTIVE, AND FOR DESIGNING RESISTANCE MITIGATION STRATEGIES. WE AIM TO 1) UNDERSTAND THE PHYSIOLOGY AND GENETICS THAT UNDERLIE BACTERIAL PERSISTENCE TO MULTIPLE OM-TARGETING AGENTS, 2) DETERMINE WHETHER THERE IS OVERLAP IN PERSISTENCE MECHANISMS TO DISTINCT OM-TARGETING AGENTS, AND 3) ASSESS EMPIRICALLY WHETHER INCREASED PERSISTENCE CAN RESULT IN INCREASED RATES OF RESISTANCE, AS WELL AS HOW PERSISTENCE CONTRIBUTES TO TREATMENT SURVIVAL IN A PLANT HOST ENVIRONMENT. THE RESULTS OF THIS RESEARCH WILL IMPROVE OUR ABILITY TO PREDICT THE POTENTIAL OUTCOMES OF OM-TARGETING ANTIMICROBIALS AND MODIFY TREATMENT STRATEGIES TO ENSURE THEIR LONG-TERM EFFECTIVENESS.
$682,500The Pennsylvania State University · · FY2022 · National Institute of Food and Agriculture
Cefixime Dose-Response in the Mouse Model of Neisseria gonorrhoeae infection
$682,194National Institute Of Allergy And Infectious Diseases · Y01 · FY2017 · AI
Redefining Tuberculosis Meningitis with Metagenomics and Host Transciptomics
$682,045Michael R Wilson · University Of California, San Francisco · R01 · FY2023 · AI
A general mechanism of persister formation
$682,044Kim Lewis · Northeastern University · R01 · FY2021 · AI
A general mechanism of persister formation
$682,044Kim Lewis · Northeastern University · R01 · FY2022 · AI
A general mechanism of persister formation
$682,044Kim Lewis · Northeastern University · R01 · FY2020 · AI
The Warburg effect and host immune response in tuberculosis
$681,641Lanbo Shi · Rbhs-New Jersey Medical School · R01 · FY2021 · AI
A randomized, double-blind, multi-center comparative effectiveness study of spironolactone versus doxycycline hyclate for the treatment of acne in women
$681,600David J. Margolis · University Of Pennsylvania · U01 · FY2025 · AR
Differential Inflammasome Regulation in the pathogenesis of S. aureus osteomyelitis
$681,592Deborah V Novack · Washington University · R01 · FY2021 · AI
Analysis of Metabolic Capabilities of Prokaryotic Cells
$681,421Jorge C Escalante · University Of Georgia · R35 · FY2020 · GM
Anti-viral Mechanisms of Defensins
$681,373Jason G Smith · University Of Washington · R01 · FY2019 · AI
Phenylacetic acid catabolism, a novel stress-response pathway in Acinetobacter baumannii
$681,308Mario Feldman · Washington University · R01 · FY2024 · AI
Targeted Clinical Research Program to Address Selected Viral Infections
$681,306Richard Whitley · University Of Alabama At Birmingham · N01 · FY2015 · AI