Sort
16,300 grants matching “fatty liver disease”
Systems genetics dissection of non-alcoholic steatohepatitis
$645,684Aldons Jake Lusis · University Of California Los Angeles · R01 · FY2021 · DK
Systems genetics dissection of non-alcoholic steatohepatitis
$645,684Aldons Jake Lusis · University Of California Los Angeles · R01 · FY2022 · DK
Systems genetics dissection of non-alcoholic steatohepatitis
$645,684Aldons Jake Lusis · University Of California Los Angeles · R01 · FY2019 · DK
Systems genetics dissection of non-alcoholic steatohepatitis
$645,684Aldons Jake Lusis · University Of California Los Angeles · R01 · FY2020 · DK
**AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** OBESITY AND ASSOCIATED DISEASES SUCH AS NON-ALCOHOLIC FATTY LIVER DISEASE (NAFLD) HAVE REACHED EPIDEMIC LEVEL.NAFLD'S GLOBAL PREVALENCE IS 20-30% IN GENERAL POPULATION AND 80% IN OBESE PEOPLE.EPIDEMIOLOGICAL DATA SUGGEST THAT DIETS THAT EMPHASIZE FRUITS AND VEGETABLE (F&V) REDUCE RISK FOR OBESITY-ASSOCIATED DISEASES INCLUDING NAFLD. HOWEVER, ONLY A FEW STUDIES USING SINGLE F&V OR THEIR EXTRACTS HAVE TESTED THIS HYPOTHESIS. OUR PRELIMINARY STUDIES SHOW THAT FEEDING MICE A DIET SUPPLEMENTED WITH 15% (W/W) OF A MIXTURE OF F&V COMMONLY CONSUMED BY AMERICANS PROTECTS AGAINST NAFLD IN OBESE AND LEAN MICE BY 48.4% AND 28.5%. THE MECHANISM FOR F&V-INDUCED PROTECTION AGAINST NAFLD IS NOT UNDERSTOOD, YET, IS URGENTLY NEEDED TO EXPAND EVIDENCE-BASED SUPPORT FOR DIETARY GUIDELINES OF INCREASE F&V CONSUMPTION TO PREVENT CHRONIC DISEASES. WHILE DIETARY INTERVENTIONS TO PREVENT NAFLD HAVE FOCUSED ON WEIGHT LOSS, LITERATURE AND OUR PRELIMINARY DATA SUGGEST THAT OTHER FACTORS THAN MAINTAINING ENERGY BALANCE CONTRIBUTE TO NAFLD DEVELOPMENT. IDENTIFYING THESE FACTORS THROUGH INVESTIGATING THE UNDERLYING MECHANISMS OF F&V-INDUCED PREVENTION OF NAFLD WILL HELP DEVELOP MORE EFFICIENT STRATEGIES TO COMBAT NAFLD. WE HAVE IDENTIFIED NOVEL PATHWAYS (CERAMIDE AND GUT MICROBIOME) THROUGH WHICH F&V MAY EXERT THEIR BENEFICIAL EFFECTS IN PREVENTING NAFLD, HOWEVER, THEIR CAUSAL ROLE AND RELATIVE CONTRIBUTION TO THE PROTECTIVE EFFECT OF F&V ARE NOT KNOWN. THUS, IN THIS PROPOSAL WE AIM TO ADDRESS THIS GAP IN KNOWLEDGE. RESULTS FROM THE PROPOSED STUDIES WILL EXPAND THE KNOWLEDGE BASE TO SUPPORT AND IMPLEMENT THE CURRENT DIETARY GUIDELINES AND HELP DEVELOP EFFECTIVE DIETARY INTERVENTIONS TO COMBAT NAFLD.
$645,464Trustees Of Tufts College · · FY2022 · National Institute of Food and Agriculture
Early Detection of Hepatocellular Carcinoma
$645,417Laura Beretta · University Of Tx Md Anderson Can Ctr · R01 · FY2016 · CA
Genetic Repair of Familial Hypercholesterolemia
$645,390William Raymond Lagor · Baylor College Of Medicine · R01 · FY2019 · HL
Genetic Repair of Familial Hypercholesterolemia
$645,390William Raymond Lagor · Baylor College Of Medicine · R01 · FY2021 · HL
Genetic Repair of Familial Hypercholesterolemia
$645,390William Raymond Lagor · Baylor College Of Medicine · R01 · FY2020 · HL
Bile acid-mediated control of lipid absorption and fatty liver disease
$645,340Thomas A Vallim · University Of California Los Angeles · R01 · FY2025 · DK
In vivo HTS assay for novel modulators of Apolipoprotein B
$645,300Steven A Farber · Carnegie Institution Of Washington, D.C. · R01 · FY2020 · DK
Epidemiology of diet, metabolism and non-alcoholic fatty liver disease in Hispanic/Latino adults
$645,272Robert C Kaplan · Albert Einstein College Of Medicine · R01 · FY2024 · DK
Understanding the Multilevel Drivers of Liver Cancer Disparities
$645,058Salma Shariff-Marco · University Of California, San Francisco · R01 · FY2020 · CA
A Sequential Multiple Assignment Randomized Trial of Diet Treatments for Hepatic Steatosis and Cardiometabolic Risk in Adolescents
$644,415Miriam B. Vos · Michigan State University · R61 · FY2025 · HL
Early Detection of Hepatocellular Carcinoma
$644,190Laura Beretta · University Of Tx Md Anderson Can Ctr · R01 · FY2020 · CA
Bile acid-mediated control of lipid absorption and fatty liver disease
$644,174Thomas A Vallim · University Of California Los Angeles · R01 · FY2024 · DK
Understanding the roles of cardiac NAD pools and therapeutic effects of precursor supplements in heart failure
$644,038Joseph A. Baur · University Of Pennsylvania · R01 · FY2024 · HL
Prebiotic effect of eicosapentaenoic acid treatment for colorectal cancer
$643,839Andrew T Chan · Massachusetts General Hospital · R01 · FY2020 · CA
Allosteric regulation of SIRT1 by a PACS-2 and DBC1 regulatory hub
$643,772Angela M. Gronenborn · University Of Pittsburgh At Pittsburgh · R01 · FY2020 · DK
Morphogenetic mechanisms of intestinal lymphatic smooth muscle-lacteal complex function and dysfunction
$643,700Natasza A Kurpios · Cornell University · R56 · FY2024 · DK
Clock modulation in circadian desynchrony induced diabetes and atherovascular disease - mechanisms and interventions
$643,423Vijay K Yechoor · University Of Pittsburgh At Pittsburgh · R01 · FY2025 · DK
Adipose MTP and FIT2 in the regulation of plasma lipids, obesity and atherosclerosis
$643,387M Mahmood Hussain · Nyu Long Island School Of Medicine · P01 · FY2023 · HL
Human population based genetic studies to elucidate the biology of NAFLD
$642,907Elizabeth K Speliotes · University Of Michigan At Ann Arbor · R01 · FY2019 · DK
Mechanisms Regulating Neurotensin Secretion and Function
$642,896Bernard Mark Evers · University Of Kentucky · R01 · FY2024 · DK
Lysosomal Regeneration (LysoGen) and Rescue as a Treatment for Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)
$642,653Mark W Grinstaff · Boston University (Charles River Campus) · R01 · FY2024 · DK