Sort
24,576 grants matching “microbiome”
Investigating the Genetic, Cellular, and Metabolic Events Important for Urothelial Homeostasis and Response to Injury
$1,200,000Cathy L Mendelsohn · Columbia University Health Sciences · U54 · FY2024 · DK
Investigating the Genetic, Cellular, and Metabolic Events Important for Urothelial Homeostasis and Response to Injury
$1,200,000Cathy L Mendelsohn · Columbia University Health Sciences · U54 · FY2025 · DK
Investigating the Genetic, Cellular, and Metabolic Events Important for Urothelial Homeostasis and Response to Urinary Tract Infection
$1,200,000Cathy L Mendelsohn · Columbia University Health Sciences · U54 · FY2019 · DK
Investigating the Genetic, Cellular, and Metabolic Events Important for Urothelial Homeostasis and Response to Injury
$1,200,000Cathy L Mendelsohn · Columbia University Health Sciences · U54 · FY2021 · DK
TO EFFECTIVELY MITIGATE ANTIMICROBIAL RESISTANCE IN THE AGRICULTURAL ECOSYSTEM, THERE IS AN INCREASING PRESSURE TO REDUCE AND ELIMINATE THE USE OF IN-FEED ANTIBIOTICS FOR GROWTH PROMOTION AND DISEASE CONTROL IN FOOD ANIMALS. HOWEVER, LIMITING ANTIBIOTICS COULD COMPROMISE PRODUCTION EFFICIENCY AND ANIMAL HEALTH. THUS, DEVELOPING EFFECTIVE ALTERNATIVES TO ANTIBIOTICS IS URGENTLY NEEDED. BUILDING UPON OUR ACCUMULATIVE RESEARCH EFFORTS ON FUNCTIONAL MICROBIOME AS WELL AS MODULATION OF HOST INNATE IMMUNITY, WE HAVE DEVELOPED TWO TYPES OF INNOVATIVE SMALL MOLECULES, NAMELY BILE SALT HYDROLASE INHIBITORS AND HOST DEFENSE PEPTIDE-INDUCING COMPOUNDS, AS ALTERNATIVES TO ANTIBIOTICS FOR GROWTH PROMOTION AND DISEASE CONTROL IN POULTRY. IN THIS PROPOSAL, WE PROPOSE TO USE INNOVATIVE AND COST-EFFECTIVE ENCAPSULATION TECHNOLOGIES TO FURTHER IMPROVE THE EFFICACY OF THESE NATURAL COMPOUNDS FOR COMMERCIAL APPLICATIONS. WE ALSO WILL DEVELOP EFFECTIVE EXTENSION AND EDUCATION PROGRAMS WHICH ARE HIGHLY INTEGRATED WITH RESEARCH TO ENCOURAGE ADOPTION OF INNOVATIVE NON-ANTIBIOTIC STRATEGIES. THE PROPOSED WORK WAS DEVELOPED WITH SIGNIFICANT INPUTS FROM STAKEHOLDERS AND RECEIVED ENTHUSIASTIC SUPPORT FROM THE INDUSTRY. THIS MULTI-DISCIPLINARY PROJECT WILL BE CONDUCTED BY A HIGHLY QUALIFIED MULTI-INSTITUTIONAL TEAM WITH MAJOR PARTICIPANTS FROM TWO USDA EPSCOR INSTITUTIONS. THE OUTCOMES OF THE PROJECT WILL LEAD TO THE DEVELOPMENT OF TWO INNOVATIVE NON-ANTIBIOTIC FEEDING TECHNOLOGIES FOR IMMEDIATE ADOPTION AND COMMERCIALIZATION IN POULTRY AND POSSIBLY OTHER LIVESTOCK, THUS MITIGATING ANTIMICROBIAL RESISTANCE ACROSS THE FOOD CHAIN.
$1,200,000University Of Tennessee · · FY2018 · National Institute of Food and Agriculture
Investigating the Genetic, Cellular, and Metabolic Events Important for Urothelial Homeostasis and Response to Injury
$1,199,999Cathy L Mendelsohn · Columbia University Health Sciences · U54 · FY2022 · DK
The Roles of Heterogeneity, Mechanics, and the Environment in Biofilm Growth and Emergent Properties
$1,199,999Howard A Stone · Princeton University · · FY2019 · BIO
The Resource of the MMRRC at UC Davis
$1,199,680Kc Kent Lloyd · University Of California At Davis · U42 · FY2024 · OD
Mechanisms of Chronic Inflammation in Periodontitis
$1,199,034Niki Moutsopoulos · National Institute Of Dental & Craniofacial Research · ZIA · FY2018 · DE
Oral Microbial and Immunological Characterization of Patients with Immune Dysfun
$1,199,034Niki Moutsopoulos · National Institute Of Dental & Craniofacial Research · ZIA · FY2018 · DE
The Resource of the MMRRC at UC Davis
$1,198,813Kc Kent Lloyd · University Of California At Davis · U42 · FY2022 · OD
Orbitrap Eclipse Tribrid Mass Spectrometer as a Regional Resource
$1,198,520Fuming Zhang · Rensselaer Polytechnic Institute · S10 · FY2023 · OD
1/3: The Chicago Cancer Health Equity Collaborative (ChicagoCHEC)
$1,198,428Melissa A. Simon · Northwestern University At Chicago · U54 · FY2021 · CA
Therapeutic targets in African-American youth with type 2 diabetes
$1,198,228Stephanie Therese Chung · National Institute Of Diabetes And Digestive And Kidney Diseases · ZIA · FY2020 · DK
Optimal chemopreventive regimens to prevent malaria and improve birth outcomes in Uganda
$1,197,862Matthew G Dorsey · University Of California, San Francisco · U01 · FY2021 · AI
A Phase 2 Trial of Axelopran Plus Pembrolizumab for the First-Line Treatment of Recurrent/Metastatic HNSCC That Is PD-L1 Positive (PD-L1CPS >1)
$1,197,275Lorin K Johnson · Glycyx Mor, Inc. · R44 · FY2025 · CA
California NeuroAIDS Tissue Network
$1,197,215David J Moore · University Of California, San Diego · U24 · FY2019 · MH
Protein Modifications Involved in Cell Signaling
$1,196,889Aleksandra Nita-Lazar · National Institute Of Allergy And Infectious Diseases · ZIA · FY2025 · AI
Disappearing gastrointestinal microbiota in epidemic obesity.
$1,196,335Martin J Blaser · New York University School Of Medicine · R01 · FY2015 · DK
1/3: The Chicago Cancer Health Equity Collaborative (ChicagoCHEC)
$1,195,987Melissa A. Simon · Northwestern University At Chicago · U54 · FY2024 · CA
Genome-Wide Association Study of Early Childhood Caries
$1,195,877Kimon Divaris · Univ Of North Carolina Chapel Hill · U01 · FY2019 · DE
1/3: The Chicago Cancer Health Equity Collaborative (ChicagoCHEC)
$1,195,558Melissa A. Simon · Northwestern University At Chicago · U54 · FY2023 · CA
The Role of Human Milk in Infant Nutrition and Health
$1,195,481Ardythe L. Morrow · Cincinnati Childrens Hosp Med Ctr · P01 · FY2009 · HD
Optimal chemopreventive regimens to prevent malaria and improve birth outcomes in Uganda
$1,194,675Matthew G Dorsey · University Of California, San Francisco · U01 · FY2020 · AI
Evaluating timing and extent of prenatal exposure to dolutegravir and early childhood outcomes
$1,194,553Jillian Pintye · University Of Washington · P01 · FY2022 · HD