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17,054 grants matching “genome editing”
Rapid ex vivo biosensor cultures to assess dependencies in gastroesophageal cancer
$800,875Jesse Samuel Boehm · Massachusetts Institute Of Technology · R01 · FY2024 · CA
Training in Translational Lung Biology and Pathobiology
$800,827Naftali Kaminski · Yale University · T32 · FY2020 · HL
Investigating the role of human-specific 3D genome conformation in the context of brain development and disease
$800,485Lucia Carbone · Oregon Health & Science University · R01 · FY2025 · MH
A National iPS Cell Network with Deep Phenotyping for Translational Research
$800,405Darrell N. Kotton · Boston University Medical Campus · U01 · FY2019 · TR
Safety and Efficacy of Human Clinical Trials Using Kidney-on-a-Chip Microphysiological Systems
$800,329Jonathan Himmelfarb · University Of Washington · UG3 · FY2021 · TR
Cas9 RNP delivery to immune cells in vivo via molecular targeting
$800,300Ross C Wilson · University Of California Berkeley · UG3 · FY2019 · AI
Development of Swine Reporter Models for Testing Somatic Cell Genome Editing Tools
$800,133Daniel Fred Carlson · Recombinetics, Inc. · U24 · FY2019 · OD
Coordinating center for collaborative marmoset research
$800,000Donald F. Conrad · Oregon Health & Science University · U24 · FY2025 · MH
Genotype-Tissue-Protein: proteomic variation and quantitative trait loci (pQTL)
$800,000Michael P Snyder · Stanford University · U01 · FY2016 · HL
THE USDA ANIMAL GENOME BLUEPRINT TARGET AREAS INCLUDE A FOCUS ON CHARACTERIZATION OF GENOME FUNCTIONAL ELEMENTS IN HIGH THROUGHPUT ASSAYS ACROSS MULTIPLE INDIVIDUALS AND BREEDS. THE NEXT MAJOR CHALLENGE FOR FUNCTIONAL ANNOTATION OF ANIMAL GENOMES (FAANG) IS TO LINK GENOMIC VARIATION IN REGULATORY SITES TO DIFFERENCES IN GENE EXPRESSION AND PHENOTYPE. THE FOCUS OF FAANG ON DEEP CHARACTERIZATION OF A FEW ANIMALS IMPLICITLY ASSUMES THOSE ANIMALS ARE REPRESENTATIVE OF THE WHOLE POPULATION. FOR MANY OF THE DATA TYPES AND TISSUES STUDIED WITHIN FAANG, THERE IS LIMITED UNDERSTANDING OF THE VARIABILITY WITHIN POPULATIONS, SUBSPECIES, OR BREEDS. WE WILL ADDRESS THIS LIMITATION OF THE FAANG APPROACH BY APPLYING CAGE-SEQ IN MANY ANIMALS. OUR PROJECT WILL (1) IDENTIFY ENHANCERS FROM WHOLE BLOOD FOR THE TWO BOVINE SUBSPECIES, AND (2) QUANTIFY THE EFFECT OF BOVINE ENHANCER VARIATION ON GENE EXPRESSION. FOR OBJECTIVE 1, WE WILL TEST THE HYPOTHESIS THAT ENHANCERS DIFFER BETWEEN AND WITHIN THE SUBSPECIES OF CATTLE. FOR OBJECTIVE 2, WE WILL TEST THE HYPOTHESIS THAT VARIATION IN ACTIVITY OF ENHANCERS ALTERS EXPRESSION OF THE GENES THEY REGULATE IN WHOLE BLOOD. AS ONE APPLICATION OF THE RESULTANT ATLAS OF ENHANCER VARIATION, WE WILL DETERMINE THE EXTENT TO WHICH VARIATION WITHIN ACTIVE ENHANCERS CONTRIBUTES TO PHENOTYPIC VARIANCE, AND THE EXPRESSION OF COMPLEX, POLYGENIC TRAITS. THE EFFECT OF ENHANCER VARIATION ON GENE EXPRESSION WILL BE STATISTICALLY VALIDATED IN AN UNRELATED POPULATION AND USING CRISPR/CAS MEDIATED GENE EDITING TO EXCHANGE ENHANCER ELEMENTS IN CULTURED BOVINE CELLS. LEVERAGING OUR UNIQUE ANIMAL RESOURCES, WE ANTICIPATE WE WILL CAPTURE A SIGNIFICANT PROPORTION OF VARIABLE ENHANCER SITES EXPECTED TO EXIST IN BLOOD WITHIN THE US BEEF HERD. OUR RESEARCH IS SIGNIFICANT BECAUSE IT WILL CONTRIBUTE TO UNDERSTANDING THE WAY IN WHICH GENE REGULATION OCCURS AT ENHANCER SITES IN THE TWO BOVINE SUBSPECIES.
$800,000Texas A&M Agrilife Research · · FY2025 · National Institute of Food and Agriculture
Collaborative Research: TRTech-PGR TRACK: Discovery and characterization of small CRISPR systems for virus-based delivery of heritable editing in plants.
$800,000Jennifer A Doudna · University Of California-Berkeley · · FY2024 · BIO
Genome Editing and Biological Effects Testing: Somatic Cell Gene Editing Testing
$799,853Jonathan A Green · University Of Missouri-Columbia · U42 · FY2023 · OD
Systems Genetics Analysis of Resilience to Tauopathy in ADRD
$799,700Karen E Duff · University College London · R01 · FY2025 · AG
The push and pull of inflammation on HIV susceptibility: impact of host variation in CD101 and AXL
$799,619Jairam Rao Lingappa · University Of Washington · R01 · FY2023 · AI
Development of Swine Reporter Models for Testing Somatic Cell Genome Editing Tools
$799,513Daniel Fred Carlson · Recombinetics, Inc. · U24 · FY2018 · OD
A National iPS Cell Network with Deep Phenotyping for Translational Research
$799,470Darrell N. Kotton · Boston University Medical Campus · U01 · FY2020 · TR
Determinants of oral anaphylaxis to food
$798,975Adam Williams · Northwestern University At Chicago · R01 · FY2024 · AI
Bioengineered red blood cells as extracellular vesicle-mediated delivery platforms for gene editing machinery
$798,810Ionita Calin Ghiran · Beth Israel Deaconess Medical Center · UG3 · FY2018 · HL
Determining stathmin-2 function and potential as a therapeutic target in ALS/FTD
$798,489Don W. Cleveland · Ludwig Institute For Cancer Res Ltd · R01 · FY2021 · NS
Focused Ultrasound-mediated Delivery of Gene-editing Elements to the Brain for Neurodegenerative Disorders
$798,469Kam W Leong · Columbia University Health Sciences · UG3 · FY2019 · NS
CD4 T cell-targeted nanoparticle in vivo delivery of CRISPR/Cas9 genome editors for HIV cure
$798,459Wenhui Hu · Temple Univ Of The Commonwealth · R01 · FY2019 · AI
Nutrient Flux and Development
$798,269Michael Krause · National Institute Of Diabetes And Digestive And Kidney Diseases · ZIA · FY2014 · DK
XenCAT: Xenopus Single Cell Atlas
$797,999Leon Peshkin · Harvard Medical School · R24 · FY2025 · OD
MeCP2 reactivation from the inactive X chromosome as treatment for Rett syndrome
$797,991X. Shawn Liu · Columbia University Health Sciences · R01 · FY2025 · MH
Identification and application of regulatory elements for heart regeneration
$797,975Kenneth D Poss · Duke University · R01 · FY2017 · HL