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38,696 grants matching “als”
PEDIATRIC AIDS CLINICAL TRIALS PROGRAM
$1,212,235Baylor College Of Medicine · U01 · FY2001 · AI
Center for American Indian Resilience
$1,212,213Priscilla Rose Sanderson · Northern Arizona University · P20 · FY2015 · MD
THIS PROPOSAL SEEKS TO UNDERSTAND TERRESTRIAL ECOSYSTEM PROCESSES THAT CONTROL THE EXCHANGES OF CO2 WITH THE ATMOSPHERE ON DECADAL AND LONGER TIME SCALES. THE APPROACH MAKES TIME SERIES MEASUREMENTS OF CO2 CONCENTRATION AND ISOTOPES AND USES THESE AND OTHER DATASETS TO CHALLENGE AND IMPROVE CARBON CYCLE MODELS INCLUDING EARTH SYSTEM MODELS. THIS PROPOSAL IS RESPONSIVE TO THE SOLICITED RESEARCH THEME #1 RELATING TO CARBON CYCLING IN ARCTIC AND BOREAL REGIONS PARTICULARLY TO CHANGES BROUGHT ABOUT BY WARMING CO2 AND NITROGEN FERTILIZATION AND ASSOCIATED CHANGES TO HYDROLOGY AND CARBON STORAGE. IT IS ALSO RESPONSIVE TO THE NEED FOR CROSS-CUTTING RESEARCH ACTIVITIES E.G. FOR IMPROVING OBSERVATIONS BY PROVIDING AN ARCHIVE OF CO2 SAMPLES TO SUPPORT DEVELOPMENT OF NOVEL ISOTOPICAPPLICATIONS RELATED TO LAND CARBON CYCLING AND IT IS RESPONSIVE TO THE NEED FOR MODELLING STUDIES IN RELATION TO ATMOSPHERIC TRANSPORT MODELLING ECOSYSTEM COMPONENT MODELLING REGIONAL AND GLOBAL MODELLING.THIS PROPOSAL WOULD PROVIDE CORE SUPPORT FOR THE MEASUREMENT ACTIVITIES OF THE SCRIPPS CO2 PROGRAM WHICH SUSTAINS MEASUREMENTS FROM A FLASK SAMPLING PROGRAM FROM AN ARRAY OF TEN STATIONS DISTRIBUTED FROM THE ARCTIC TO THE ANTARCTIC INCLUDING THE ICONIC MAUNA LOA CONTINUOUS RECORD. THE PROGRAM COMPLEMENTS THE LARGER NOAA ESRL PROGRAM BY PROVIDING CRITICAL REDUNDANCY FOR STATE OF THE ART MEASUREMENTS BY ENSURING CONTINUITY OF THE LONGEST RECORDS OF CRITICAL IMPORTANCE AND PROVIDING INTERPRETIVE CAPABILITIES FOR UNDERSTANDING THE DATA SIGNIFICANCE. THE PROGRAM ALSO COMPLEMENTS THE DOE MODELLING (ACME) AND MEASUREMENTS PROGRAMS (NGEE-ARCTIC FACE AMERIFLUX) BY PROVIDING CROSS CUTTING CONSTRAINTS ON LARGE-SCALE CARBON CYCLING AND IT IS HIGHLY RELEVANT TO THE DOE SCIENTIFIC FOCUS AREA ON BIOGEOCHEMISTRY/CLIMATE FEEDBACKS. BY SUSTAINING THE LONGEST RECORDS OF CO2 AND ISOTOPES ANDADVANCING RELATED INTERPRETIVE CAPABILITIES THE SCRIPPS PROGRAM IS WELL POSITIONED TO MAKE AGENDA SETTING DISCOVERIES RELATED TO CARBON CYCLING AND CARBON/CLIMATE FEEDBACKS.IN ADDITION TO SUPPORTING THE CONTINUATION OF THESE OBSERVATIONS AND THEIR IMPROVEMENT THIS PROPOSAL WILL SUPPORT A COLLABORATION WITH DRS. PETER THORNTON AND LIANHONG GU OF ORNL WHICH BUILDS ON TWO RECENT SIGNIFICANT DISCOVERIES FROM THE PROGRAM. THE FIRST IS THE EVIDENCE OF THE LARGE INCREASE IN THE SEASONAL AMPLITUDE AT HIGH NORTHERN LATITUDES DOCUMENTED BY GRAVEN ET AL. (2013). THESECOND IS EMERGENT EVIDENCE FOR A SHIFT TOWARDS HIGHER PHOTOSYNTHETIC DISCRIMINATION BOTH GLOBALLY AND AT HIGH NORTHERN LATITUDES.BOTH DISCOVERIES ARE HIGHLY RELEVANT FOR UNDERSTANDING ONGOING CHANGES IN ARCTIC AND BOREAL ECOSYSTEMS. BOTH POTENTIALLY PROVIDE CRITICAL INSIGHTS INTO THE COUPLED CARBON NITROGEN AND WATER CYCLING IN THE CONTEXT OF ONGOING CHANGES. THE COLLABORATION WILL ENTAIL COMBINED DATA SYNTHESIS AND MODELLING ACTIVITIES TAKING ADVANTAGE OF RECENT ADVANCES IN GLOBAL AND PLANT-LEVEL MODELLING CAPABILITIES AT ORNL. THE COLLABORATION IS AIMED AT ANSWERING THESE KEY QUESTIONS:(1) HOW CAN THE OBSERVED SEASONAL CYCLES IN CO2 CONCENTRATION BE USED TO CONSTRAIN THE REPRESENTATION OF NITROGEN CYCLING WITHIN LAND SURFACE MODELS?(2) HOW DOES THE FORMULATION OF NITROGEN CYCLING IN MODELS IMPACT THE PREDICTED PHOTOSYNTHETIC DISCRIMINATION ON SEASONAL TIME SCALES?(3) WHAT PLAUSIBLE CHANGES IN LEAF LEVEL PROCESSES CAN ACCOUNT FOR THE LONG-TERM CHANGES IN PHOTOSYNTHETIC DISCRIMINATION SUGGESTED BY ATMOSPHERIC DATA?
$1,212,095University Of California San Diego · · FY2017 · National Aeronautics and Space Administration
Neuronal avalanches in the neocortex
$1,212,051Dietmar Plenz · National Institute Of Mental Health · ZIA · FY2010 · MH
Mechanisms of Virus Entry into Cells and Antiviral Barriers Limiting Entry
$1,211,915Alex Compton · Division Of Basic Sciences - Nci · ZIA · FY2025 · CA
Mitochondrial transport: impact on synaptic transmission and neurodegeneration
$1,211,826Zu-Hang Sheng · National Institute Of Neurological Disorders And Stroke · ZIA · FY2012 · NS
Genetically Engineered Mouse Models to Study Melanoma Genesis and Progression
$1,211,771Glenn T. Merlino · Division Of Basic Sciences - Nci · ZIA · FY2023 · CA
Preclinical Mouse Models for Studying Immune Checkpoint Inhibitor Response
$1,211,771Glenn T. Merlino · Division Of Basic Sciences - Nci · ZIA · FY2023 · CA
Development of a Microphysiological Organ-on-Chip System to Model Amyotrophic
$1,211,519Clive Niels Svendsen · Cedars-Sinai Medical Center · UH3 · FY2021 · NS
Genetic Analysis of Attention Deficit Hyperactivity Disorder
$1,211,467Maximilian Muenke · National Human Genome Research Institute · ZIA · FY2011 · HG
CAMELLIA Cohort: A longitudinal study to understand sexual health and prevention among women in Alabama
$1,211,161Latesha Ellen Elopre · University Of Alabama At Birmingham · R01 · FY2023 · HD
Magnetic Resonance Spectroscopy Core Facility
$1,211,051Jun Shen · National Institute Of Mental Health · ZIC · FY2023 · MH
EXPLORING NOVEL ALS BIOMARKERS: MULTIOMICS APPROACH UTILIZING IMMUNOPROFILING. EXTRACELLULAR VESICLE ANALYSIS, AND TDP-43 AGGREGATION ASSAYS.
$1,210,500Mayo Clinic · · FY2025 · Defense Health Agency
Membrane Remodeling in Viral Infection and Viral Assembly
$1,210,393Joshua Zimmerberg · Eunice Kennedy Shriver National Institute Of Child Health & Human Development · ZIA · FY2025 · HD
Gulf Longitudinal Follow-up (GuLF) Study
$1,209,935Dale P Sandler · National Institute Of Environmental Health Sciences · ZIA · FY2017 · ES
Thailand HIV/AIDS and Infectious Disease Clinical Trials Unit (THAI CTU)
$1,209,654Suwat Chariyalertsak · Chiang Mai University · UM1 · FY2016 · AI
Axonal transport regulates synaptic function and axonal homeostasis
$1,208,886Zu-Hang Sheng · National Institute Of Neurological Disorders And Stroke · ZIA · FY2013 · NS
Molecular Basis of Obesity and Obesity-induced Metabolic Diseases
$1,207,700Haiming Cao · National Heart, Lung, And Blood Institute · ZIA · FY2015 · HL
Neural Coding of Visual Stimuli
$1,206,914Barry J Richmond · National Institute Of Mental Health · ZIA · FY2016 · MH
Center for American Indian Resilience
$1,206,570Priscilla Rose Sanderson · Northern Arizona University · P20 · FY2014 · MD
Long-term health and socioeconomic impact of interventions targeting low-density malaria infection (LMI) among children in Tanzania
$1,206,533Michelle Sang Hsiang · University Of California, San Francisco · U01 · FY2023 · AI
Targeting negative affect through mindfulness training in youth at risk for internalizing problems
$1,206,184Judy Garber · Vanderbilt University · R33 · FY2023 · MH
Signal Transduction Events and the Regulation of Cell Growth
$1,205,526Jane B Trepel · Division Of Clinical Sciences - Nci · ZIC · FY2022 · CA
American Indian Diabetes Prevention Center: Impacting Health Disparity in Youth
$1,205,131Thomas Allen Teasdale · University Of Oklahoma Hlth Sciences Ctr · P20 · FY2016 · MD
High channel count electrophysiology and data processing for freely-moving animals
$1,205,009John L Sherwood · Leaflabs, Llc · R44 · FY2022 · MH