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15,440 grants matching “organoids”
Tissue destruction and healing in Celiac Disease
$2,394,001Bana Jabri · University Of Chicago · RC2 · FY2023 · DK
Elucidate the roles of Alzheimer's disease risk genes and variants in gene expression and AD-related phenotypes
$2,393,458Yin Shen · University Of California, San Francisco · RF1 · FY2025 · AG
Scalable and transplantable pancreatic islet organoids with engineered oxygenation
$2,390,830Hirotake Komatsu · University Of California, San Francisco · R01 · FY2025 · DK
Microbiome Discovery and Mechanisms to Combat Antibiotic Resistance at Mucosal Surfaces
$2,390,117Robert A Britton · Baylor College Of Medicine · U19 · FY2021 · AI
Genetics and Biology of Pancreatic Ductal Adenocarcinoma
$2,385,495Ronald Anthony Depinho · University Of Tx Md Anderson Can Ctr · P01 · FY2025 · CA
Epilepsy Multiplatform Variant Prediction (EpiMVP)
$2,382,073Lori L Isom · University Of Michigan At Ann Arbor · U54 · FY2023 · NS
Epilepsy Multiplatform Variant Prediction (EpiMVP)
$2,382,072Lori L Isom · University Of Michigan At Ann Arbor · U54 · FY2022 · NS
The Duke Senescent Cell Evaluations in Normal Tissues (SCENT) Mapping Center
$2,381,000Andrew B Nixon · Duke University · U54 · FY2022 · AG
OUR OVERALL OBJECTIVE IS TO DETERMINE THE SHORT- AND LONG-TERM RISKS OF RADIATION FROM THE SPACE ENVIRONMENT ON COGNITION MOTOR ABILITIES FATIGUE RESISTANCE ANXIETY AND CHANGES IN THE BRAIN AND CARDIOVASCULAR SYSTEM. OVER THE PAST 3 YEARS WE HAVE DETERMINED THAT LOW-DOSE 56FE (IRON) RADIATION HAS LONG-TERM SEX-SPECIFIC CONSEQUENCES ON COGNITION LOCOMOTION NEUROINFLAMMATION AND ALZHEIMERS DISEASE (AD) PATHOGENESIS WITH MALES BEING MORE VULNERABLE THAN FEMALES. ANALYSIS OF PROTON-IRRADIATED MICE IS UNDERWAY. OVER THE PAST YEAR WE HAVE DEVELOPED A COLLABORATION WITH DR. DORIS TAYLOR (TEXAS HEART INSTITUTE) CO-I ON THIS PROPOSAL BY SHARING THE HEART ONE KIDNEY AND BONE MARROW FROM EACH OF THE MICE IRRADIATED IN THREE OF OUR STUDIES. OVER THE NEXT 4 YEARS WE WILL EXTEND OUR RESEARCH BY COMPARING OUR EXISTING DATA FROM OUR CURRENT STUDIES ON THE LATE CENTRAL NERVOUS SYSTEM (CNS) AND CARDIOVASCULAR (CV) EFFECTS OF A SINGLE DOSE OF IRON RADIATION OR A SINGLE DOSE OF PROTONS WITH A SINGLE DOSE OF OXYGEN-16 OR MIXED BEAM GCR (PROTONS OXYGEN-16 AND IRON) IN MALE AND FEMALE AD-LIKE TRANSGENIC AND WILDTYPE MICE AND GAMMA IRRADIATED WILDTYPE MICE (AIM 1). IN ADDITION WE WILL EXAMINE THE SEX- AND APO E-SPECIFIC LATE CNS AND CV DOSE-SPECIFIC EFFECTS OF IRON RADIATION IN THE SAME AD-LIKE MOUSE MODEL MODIFIED BY TARGETED REPLACEMENT OF MURINE APO E WITH HUMAN APO E3 OR E4 TO DETERMINE IF HUMAN APOE4 A STRONG RISK FACTOR FOR AD AND CV DISEASE EXACERBATES THE EFFECTS OF RADIATION (AIM 2). THIS WORK WILL BE CONDUCTED IN COLLABORATION WITH INVESTIGATORS AT WASH U DUKE U AND NYU. WE WILL PERFORM LONGITUDINAL MAGNETIC RESONANCE IMAGING (MRI) ON THE BRAIN AND HEART IN A SUBSET OF MICE IN AIMS 1 AND 2 TO DETERMINE RADIATION-INDUCED CHANGES WITHIN INDIVIDUAL ANIMALS. IN ADDITION MICE WILL UNDERGO EXTENSIVE BEHAVIORAL TESTING AS WELL AS PATHOLOGICAL AND BIOCHEMICAL ANALYSIS OF BRAIN AND HEART. LASTLY WE WILL CONDUCT A STUDY TO TEST 2 NOVEL HUMAN 3D NEURAL ORGANOID MODELS OF ALZHEIMERS DISEASE DEVELOPED BY OUR COLLABORATORS AT MGH AND MIT (AIM 3) FOR ACUTE AND LATE CNS EFFECTS OF SPACE RADIATION ON NEURONAL HEALTH AMYLOID PLAQUES TAU PATHOLOGY AND EPIGENETICS AND TO INVESTIGATE THE POTENTIAL OF THESE MODELS FOR SCREENING MITIGATING TREATMENTS IN THE FUTURE. IN COLLABORATION WITH DR. TAYLOR WE WILL ALSO IRRADIATE UNDIFFERENTIATED INDUCED PLURIPOTENT STEM CELLS (IPSCS) FROM HUMAN MALES AND FEMALES TO DETERMINE WHETHER HIGHLY CHARGED HIGH ENERGY (HZE) PARTICLE IRRADIATION ALTERS THEIR ABILITY TO DIFFERENTIATE INTO CARDIOMYOCYTES MORPHOLOGY AND/OR MATURATION. IN SUMMARY WE PROPOSE TO TAKE OUR CURRENT STUDIES TO THE NEXT LOGICAL STEP IN AN EFFORT TO BETTER UNDERSTAND THE POTENTIAL RISKS OF GALACTIC COSMIC RADIATION (GCR) TO THE BRAIN AND CARDIOVASCULAR SYSTEM IN ORDER TO PREPARE ASTRONAUTS FOR LONG-TERM DEEP SPACE MISSION INCLUDING MISSIONS TO MARS.
$2,376,960Brigham & Womens Hospital Inc · · FY2020 · National Aeronautics and Space Administration
Epilepsy Multiplatform Variant Prediction (EpiMVP)
$2,376,529Lori L Isom · University Of Michigan At Ann Arbor · U54 · FY2021 · NS
Genetics and Biology of Pancreatic Ductal Adenocarcinoma
$2,375,289Ronald Anthony Depinho · University Of Tx Md Anderson Can Ctr · P01 · FY2023 · CA
Developing Human Pluripotent Stem Cell Tools for Region-Specific Pain Circuits
$2,370,000Nisha Iyer · Tufts University Medford · DP2 · FY2024 · NS
E-Organoids: Functional Brain Organoids Co-grafted with Transparent Microthreads
$2,368,875Duygu Kuzum · University Of California, San Diego · DP2 · FY2020 · EB
The role of PKD proteins in regulating tubular morphology
$2,367,163Gregory Germino · National Institute Of Diabetes And Digestive And Kidney Diseases · ZIA · FY2024 · DK
EFRI DCheM: Distributed Manufacturing of Personalized Medicines
$2,364,800Max Shtein · Regents Of The University Of Michigan - Ann Arbor · · FY2021 · ENG
Understanding neuronal dysfunction in Down Syndrome using assembloids and xenotransplanted cortical organoids
$2,357,335Ella Zeldich · Boston University Medical Campus · RF1 · FY2024 · AG
Modeling developmental gradients and supportive tissue signaling networks using iPSC-derived forebrain organoids embedded in fluidic hydrogels
$2,347,168Vivian Gama · Vanderbilt University · RF1 · FY2020 · MH
Brain-muscle microphysiological system enabled extracellular vesicle network for understanding aging in space
$2,344,810Mei He · University Of Florida · UG3 · FY2025 · TR
Dark GPCR signaling underlying the Microbiome-Gut-Brain Axis for Alzheimer's Disease and Related Dementia
$2,344,291Feixiong Cheng · Cleveland Clinic Lerner Com-Cwru · RF1 · FY2023 · NS
Engineering multi-organs in a dish
$2,342,351Takanori Takebe · Cincinnati Childrens Hosp Med Ctr · DP2 · FY2020 · DK
Cellular, molecular, and functional imaging approaches to understanding early neurodevelopment in autism
$2,341,384Katarzyna Chawarska · Yale University · P50 · FY2019 · MH
Understanding the functional impacts of Aβ variants in Alzheimer's disease with human brain organoids
$2,333,853Zhexing Wen · Emory University · RF1 · FY2022 · AG
Genetics and Biology of Pancreatic Ductal Adenocarcinoma
$2,327,780Ronald Anthony Depinho · University Of Tx Md Anderson Can Ctr · P01 · FY2022 · CA
Proteome-Driven Holistic Reconstruction of Organ-Wide Multi-Scale Networks
$2,322,968Kwanghun Chung · Massachusetts Institute Of Technology · DP2 · FY2016 · ES
Nextgen AD Models, Endotypes, and Screening
$2,319,456Shankar Subramaniam · University Of California, San Diego · RF1 · FY2024 · AG