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15,440 grants matching organoids

Lineage Plasticity, due to Disruption of MnSOD Biology, drives resistance to Ionizing Radiation / Androgen Deprivation Therapy

$376,114
David Gius · University Of Texas Hlth Science Center · R01 · FY2022 · CA

Coordinate Regulation of Oncogenic Signaling Pathways in SPOP Mutant Prostate Cancer

$376,098
Christopher E Barbieri · Weill Medical Coll Of Cornell Univ · R37 · FY2019 · CA

Project 2: Combined personal neoantigen-targeting cancer vaccines with immune checkpoint blockade for ovarian cancer

$376,043
Panagiotis Konstantinopoulos · Dana-Farber Cancer Inst · P50 · FY2022 · CA

Mechanistic Impact of PI3K/mTOR Signaling on Intestinal Homeostasis

$375,915
Bernard Mark Evers · University Of Kentucky · R01 · FY2021 · DK

Mechanistic Impact of PI3K/mTOR Signaling on Intestinal Homeostasis

$375,915
Bernard Mark Evers · University Of Kentucky · R01 · FY2022 · DK

Mechanistic Impact of PI3K/mTOR Signaling on Intestinal Homeostasis

$375,915
Bernard Mark Evers · University Of Kentucky · R01 · FY2023 · DK

Mechanistic Impact of PI3K/mTOR Signaling on Intestinal Homeostasis

$375,915
Bernard Mark Evers · University Of Kentucky · R01 · FY2020 · DK

Tumor-intrinsic and paracrine roles of endoglin in pancreatic cancer

$375,820
Nam Y Lee · University Of Arizona · R01 · FY2025 · CA

Lipid Metabolism Switch Triggers Invasive and Chemoresistant Epithelial Ovarian Cancer Phenotype

$375,748
Michelle R Dawson · Brown University · R01 · FY2023 · CA

Project 2: Predicting Treatment Responses Using Single Cell RNA Sequencing and Bioengineered Patient-derived Organotypic Models of HNC

$375,726
David J Beebe · University Of Wisconsin-Madison · P50 · FY2025 · CA

Regulation of gastric metaplasia, dysplasia and neoplasia by Bone Morphogenetic Protein signaling

$375,677
Andrea Todisco · University Of Michigan At Ann Arbor · R56 · FY2017 · DK

The role of immunosuppression in the tumor microenvironment in Hispanic/Latino patients with breast cancer

$375,635
Evanthia Theodosiou Roussos Torres · University Of Southern California · P20 · FY2024 · CA

Defining signaling networks in epithelial homeostasis

$375,591
Curtis Andrew Thorne · University Of Arizona · R35 · FY2025 · GM

Research Project 1: Enhancing neoadjuvant therapy to prevent breast cancer recurrence

$375,574
Michael T Lewis · University Of Utah · U54 · FY2024 · CA

Project 3: Characterization of Beta-Catenin Degraders for the Treatment of Colorectal Cancer

$375,570
Stephen W. Fesik · Vanderbilt University Medical Center · P50 · FY2025 · CA

Overcoming primary and secondary resistance in wild-type BRAF melanoma

$375,350
Andrew E Aplin · Wistar Institute · P01 · FY2021 · CA

Strategies for Receptor inhibition in immunotherapy

$375,318
Kenan Christopher Garcia · Stanford University · R01 · FY2025 · CA

Single cell modeling of cancer mutations

$375,297
Hanlee Ji · Stanford University · R33 · FY2023 · CA

Cytokine regulation of intestinal epithelial restitution

$375,187
D. Brent Polk · Children'S Hospital Of Los Angeles · R01 · FY2017 · DK

Spatial control of membrane traffic by septin GTPases

$375,185
Elias T Spiliotis · Drexel University · R35 · FY2022 · GM

Exploiting Pyrimidine Nucleotide Synthesis Dependence for IDH Mutant Glioma Therapy

$375,150
Samuel Kent McBrayer · Ut Southwestern Medical Center · R01 · FY2022 · CA

Exploiting Pyrimidine Nucleotide Synthesis Dependence for IDH Mutant Glioma Therapy

$375,150
Samuel Kent McBrayer · Ut Southwestern Medical Center · R01 · FY2025 · CA

Hereditary Cancer Variants of Uncertain Significance in Stem Cells

$375,150
Christopher D. Heinen · University Of Connecticut Sch Of Med/Dnt · R01 · FY2020 · CA

Elucidating the Role of Perivascular Niche in Glioblastoma Invasion and Therapeutic Resistance at Single Cell Resolution using Biomimetic Tumor Microenvironment Models

$375,134
Mehdi Nikkhah · Arizona State University-Tempe Campus · R01 · FY2025 · NS

Overcoming primary and secondary resistance in wild-type BRAF melanoma

$375,106
Andrew E Aplin · Wistar Institute · P01 · FY2019 · CA