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15,440 grants matching “organoids”
Mechanisms by which histone methyltransferases regulate nuclear receptor activity and response to therapy in hormone-driven tumors.
$374,578Eneda Toska · Johns Hopkins University · R01 · FY2023 · CA
Organoid modeling to determine and reverse age-related epigenetic changes contributing to risk of colorectal cancer
$374,578Stephen B Baylin · Johns Hopkins University · R01 · FY2019 · CA
(PQ4) - Tools for simultaneous disruption of multiple epigenetically silenced genes for studying their roles in tumorigenesis using ex vivo human and mouse colon organoid and in vivo mouse models
$374,578Hariharan Easwaran · Johns Hopkins University · R01 · FY2021 · CA
Mechanisms by which histone methyltransferases regulate nuclear receptor activity and response to therapy in hormone-driven tumors.
$374,578Eneda Toska · Johns Hopkins University · R01 · FY2025 · CA
(PQ4) - Tools for simultaneous disruption of multiple epigenetically silenced genes for studying their roles in tumorigenesis using ex vivo human and mouse colon organoid and in vivo mouse models
$374,578Hariharan Easwaran · Johns Hopkins University · R01 · FY2020 · CA
The kynurenine-AHR pathway in biomass production
$374,578Maralice Conacci-Sorrell · Ut Southwestern Medical Center · R01 · FY2021 · CA
Organoid modeling to determine and reverse age-related epigenetic changes contributing to risk of colorectal cancer
$374,578Stephen B Baylin · Johns Hopkins University · R01 · FY2020 · CA
Michigan Hepatotoxicity Clinical Research Network Renewal
$374,400Robert J Fontana · University Of Michigan At Ann Arbor · U01 · FY2024 · DK
Preclinical analyses of advanced prostate cancer in genetically-engineered mice
$374,307Cory Abate-Shen · Columbia University Health Sciences · R01 · FY2019 · CA
CRISPR-Cas9 based treatment of dominant retinal degeneration
$374,300Edwin M Stone · University Of Iowa · R01 · FY2022 · EY
Hereditary Cancer Variants of Uncertain Significance in Stem Cells
$374,293Christopher D. Heinen · University Of Connecticut Sch Of Med/Dnt · R01 · FY2019 · CA
Aging-associated mammary cancer-initiating cells
$374,266Luzhe Sun · University Of Texas Hlth Science Center · U01 · FY2022 · CA
Aging-associated mammary cancer-initiating cells
$374,266Luzhe Sun · University Of Texas Hlth Science Center · U01 · FY2023 · CA
CD8 T cell derived Granzyme K activates complement that drives synovial fibroblast inflammation
$374,194Michael B Brenner · Brigham And Women'S Hospital · R01 · FY2024 · AR
Dietary Flavonoids-Microbiota-Ah Receptor Interactions in the Gut
$374,064Stephen H Safe · Texas A&M Agrilife Research · R01 · FY2018 · AT
Targeting DNA Ligase I in Ovarian Cancer
$374,061Alan E Tomkinson · University Of New Mexico Health Scis Ctr · R01 · FY2023 · CA
Role of the smooth muscle layer in bladder cancer biology and progression: a systems and experimental approach
$374,052Ashley Marie Laughney · Weill Medical Coll Of Cornell Univ · R21 · FY2022 · CA
DNA Methylation and Hydroxymethylation During Retinal Development and Stem Cell Maintenance
$374,032Jeffrey Gross · University Of Pittsburgh At Pittsburgh · R01 · FY2021 · EY
Patterning Genes in Retinal Development
$374,028Deborah L Stenkamp · University Of Idaho · R01 · FY2018 · EY
Project 2: Translational Significance of a Mutational Signature of African American Colon Cancers
$373,975Joseph Edward Willis · Case Western Reserve University · P50 · FY2019 · CA
Targeting SUMO1 degradation for advanced colon cancer therapy
$373,955Anita Bellail · Indiana University Indianapolis · R01 · FY2023 · CA
Matching panels of in vivo and in vitro model system of pediatric brain tumors
$373,865Xiaonan Li · Lurie Children'S Hospital Of Chicago · U01 · FY2024 · CA
Role of PD2/Paf1 in Pancreatic Acinar to Ductal Metaplasia
$373,823Moorthy P. Ponnusamy · University Of Nebraska Medical Center · R01 · FY2018 · CA
Role of PD2/Paf1 in Pancreatic Acinar to Ductal Metaplasia
$373,823Moorthy P. Ponnusamy · University Of Nebraska Medical Center · R01 · FY2017 · CA
Modeling Zika virus pathogenesis and potential intervention during neural development using a human brain organoid system
$373,787Hengli Tang · University Of Pennsylvania · U19 · FY2018 · AI