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15,440 grants matching “organoids”
Three-dimensional organoid culture using the CellRaft microwell technology
$300,161Steven Charles Gebhart · Cell Microsystems, Inc. · R43 · FY2019 · GM
IRES Track I: Advanced Imaging and Characterization at the Interface Between Living and Nonliving Materials
$300,000Hsin-Chiao D Ou-Yang · Lehigh University · · FY2022 · O/D
Proof of concept experiments for T3SS inhibitors against burn wound infections
$300,000Timothy J Opperman · Microbiotix, Inc · R41 · FY2024 · AI
THE LONG-TERM GOAL OF THIS PROPOSAL IS TO STUDY THE EFFECTS OF MODELED MICROGRAVITY AND PARTIAL GRAVITY ON AGGREGATE (ORGANOID) CULTURES OF INDUCED PLURIPOTENT STEM CELLS (IPSCS). OUR WORKING HYPOTHESIS BASED ON SOME PRELIMINARY DATA IS THAT HYPOGRAVITY I.E. MODELED MICROGRAVITY AND/OR PARTIAL GRAVITY WILL ENHANCE IPSC DIFFERENTIATION INTO THE ENDODERMAL LINEAGES. SPECIFICALLY WE WILL COMPARE THE EFFICIENCY OF TWO DISTINCT MICROGRAVITY GRAVITY / PARTIAL GRAVITY SIMULATING DEVICES I.E. THE ROTATING WALL VESSEL (RWV) BIOREACTOR AND RANDOM POSITIONING MACHINE (RPM) TO MODULATE THE MAINTENANCE OF IPSCS STEMNESS AND THE DIRECTED DIFFERENTIATION OF IPSC INTO DEFINITIVE ENDODERM. IN TESTING OUR HYPOTHESIS WE DEVELOPED THE FOLLOWING SPECIFIC AIMS: SPECIFIC AIM 1. TO CHARACTERIZE THE DIFFERENTIATION OF IPSC INTO DEFINITIVE ENDODERM IN 2D MONOLAYER CULTURE IN NORMAL AND SIMULATED PARTIAL- (MOON MARS) AND MICROGRAVITY; AND IN 3D AGGREGATE SUSPENSION CULTURE IN PARTIAL- (RPM) AND MICROGRAVITY (RPM AND RWV). SPECIFIC AIM 2. EXAMINE THE UNDERLYING GENETIC EPIGENETIC MOLECULAR AND BIOCHEMICAL MECHANISMS OF STEM CELL DIFFERENTIATION AND BEHAVIOR THAT ARE AFFECTED BY AGGREGATE CULTURE HYPOXIA AND HYPOGRAVITY; AND IDENTIFY SPECIFIC MOLECULAR AND SIGNALING FACTORS IMPORTANT IN MODULATION OF DIFFERENTIATION. IN THESE STUDIES WE WILL USE BIOCHEMICAL IMMUNOLOGICAL AND MOLECULAR BIOLOGICAL APPROACHES TO ANALYZE THE DIFFERENTIAL EXPRESSION OF A SET OF LINEAGE-SPECIFIC SPECIFIC MARKER GENES AND GENE PRODUCTS UNDER ALTERED GRAVITY CONDITIONS. SUBSEQUENTLY WE WILL IDENTIFY SPECIFIC GENETIC EPIGENETIC AND MOLECULAR MECHANISMS THAT UNDERLIE AND ARE INFLUENCED BY PARTIAL- AND MICROGRAVITY AND COMPARE THESE BIOLOGIC FACTORS WITH THOSE FROM INDUCED IPSC DIFFERENTIATION IN BOTH AGGREGATE AND MONOLAYER CULTURE IN STANDARD GRAVITY. THE LATTER DATA WILL BE ANALYZED BY SYSTEMS- / BIOINFORMATICS-BASED ANALYTICAL APPROACHES SUCH AS PRINCIPAL COMPONENT ANALYSIS AND NETWORK ANALYSIS WHICH WILL HELP TO IDENTIFY SPECIFIC HYPOGRAVITY-SENSITIVE CELLULAR SIGNALING MOLECULES AND PATHWAYS THAT MAY BE DIFFERENTIALLY AFFECTED BY VARYING LEVELS OF PARTIAL/MICRO-GRAVITY AND WHICH COULD BE FURTHER EXPLORED IN ACTUAL SPACE EXPERIMENTS. IN ADDITION TO HAVING AVAILABLE BOTH HYPOGRAVITY SIMULATING DEVICES WE HAVE INTRODUCED SEVERAL TECHNICAL INNOVATIONS SUCH AS MODIFICATIONS IN THE RWV BIOREACTORS ENHANCED OXYGENATION CAPABILITIES IN RPM CULTURE AND A HIGH-RESOLUTION OPTICAL MONITORING SYSTEM THAT ALLOWS REAL-TIME VISUALIZATION OF INTRACELLULAR SIGNALING EVENTS. WE ANTICIPATE THAT WE WILL DEMONSTRATE A SUPERIOR ENVIRONMENT FOR IPSC DIFFERENTIATION IN SIMULATED AND/OR PARTIAL GRAVITY CONDITIONS AND THAT KNOWLEDGE GAINED FROM THESE STUDIES WILL CONTRIBUTE TO TECHNOLOGICAL AND MEDICAL ADVANCEMENTS BOTH ON EARTH AND IN SPACE AND ENHANCE OUR UNDERSTANDING OF THE ADAPTATION AND FUNCTION OF BIOLOGICAL PROCESSES IN ALTERED GRAVITY.
$300,000Temple University-Of The Commonwealth System Of Higher Education · · FY2020 · National Aeronautics and Space Administration
Collaborative Research: Chimeric Antigen Receptor Engineered Neutrophil Extracellular Vesicles Targeting Glioblastoma
$300,000Xiaoping Bao · Purdue University · · FY2025 · ENG
Real-time intracellular monitoring of microRNAs in human stem cell-derived insulin producing organoids
$300,000Catherine Digovich · Minutia, Inc. · R43 · FY2021 · DK
A HUMAN BRAIN ORGANOID PLATFORM TO BENCHMARK BIOMARKERS FOR TRAUMATIC BRAIN INJURY SEVERITY
$300,000University Of California, San Diego · · FY2022 · Defense Health Agency
Collaborative Research: RECODE: On-line Feedback Control of Human Mesenchymal Stem Cell Chondrogenesis
$300,000Lawrence J Bonassar · Cornell University · · FY2022 · ENG
Targeting Covid-19 with a Therapeutic Interfering Particle
$300,000Raul Andino · Aleph Therapeutics, Inc. · R41 · FY2021 · AI
Proof of concept experiments for T3SS inhibitors against burn wound infections
$300,000Timothy J Opperman · Microbiotix, Inc · R41 · FY2025 · AI
IGF::OT::IGF SBIR Topic 355: An Organoid Avatar Biobank for Cancer Disparities. To establish a colorectal cancer organoid avatar bio-bank from an ethnically and genetically diverse patient populatio
$300,000Carolyn Bannister · Delphi Genomics, Llc · N43 · FY2017 · CA
Collaborative Research: Bioengineering thymus organoids towards generation of humanized mice models
$300,000Ipsita Banerjee · University Of Pittsburgh · · FY2018 · ENG
USC GUDMAP Coordinating Center
$300,000Carl Kesselman · University Of Southern California · U24 · FY2017 · DK
EAGER: Bioprinting Personalized Islets
$300,000Kaiming Ye · Suny At Binghamton · · FY2014 · ENG
Development of a stem-cell derived thymic cell therapy to treat patients with athymia
$299,999Bing Lim · Thymmune Therapeutics, Inc · R44 · FY2022 · AI
Developing a peptide-based oral drug to prevent kidney stones
$299,998Donna Arvans · Oxalo Therapeutics, Inc. · R42 · FY2018 · DK
Collaborative Research: Bioengineering Thymus Organoids Towards Generation Of Humanized Mice Models
$299,998Yong Fan · Allegheny-Singer Research Institute · · FY2018 · ENG
NSF2026: EAGER: The evolution and diversity of the human brain
$299,990Richard E Green · University Of California-Santa Cruz · · FY2020 · SBE
Development of Antibiotic-Free Clostridium difficile Therapeutics
$299,984Raquel Hontecillas · Biotherapeutics, Inc. · R43 · FY2019 · AI
BCN057 as a mitigator of Radiation Induced Gastrointestinal Syndrome
$299,857Andrew John Norris · Bcn Biosciences, Llc · R43 · FY2019 · AI
HBCU-UP: EAGER: Cortical Organoid-Vasculature Intelligence
$299,844Yeoheung Yun · North Carolina Agricultural & Technical State University · · FY2024 · EDU
Custom-engineering a 3D brain organoid platform to model viral infections of the central nervous system
$299,833Guo-Li Ming · University Of Pennsylvania · U19 · FY2021 · AI
Modeling Zika virus pathogenesis and potential intervention during neural development using a human brain organoid system
$299,832Hengli Tang · University Of Pennsylvania · U19 · FY2021 · AI
Administrative Core
$299,832Guo-Li Ming · University Of Pennsylvania · U19 · FY2021 · AI
Generation and molecular characterization of multiple human neural cell types
$299,832Zhexing Wen · University Of Pennsylvania · U19 · FY2021 · AI